慢性肾炎患者内皮素、降钙素基因相关肽变化的临床意义  

Change of Endothelins and Calcitonin Gene—Related Peptide in Patients Suffering Chronic Nephritis

作　　者：王力增[1] 黄雯[1] 姜丽萍[1] 代浩洁 王颖 

机构地区：[1]首都医科大学附属北京同仁医院肾内科 [2]同仁医院核医学科

出　　处：《首都医科大学学报》2004年第1期89-91,共3页Journal of Capital Medical University

摘　　要：为探讨内皮素 (ET)和降钙素基因相关肽 (CGRP)在慢性肾炎肾衰竭失代偿期的病理意义及其与肾小球滤过率 (GFR)的关系 ,采用放射免疫法检测 36例慢性肾炎肾衰竭失代偿期患者血及尿中的ET和CGRP质量浓度 ,同时测定GFR。结果 :慢性肾炎肾衰竭失代偿期患者ET质量浓度血浆为 ( 72 .4 5± 2 0 .6 5)ng/L〔对照组 ( 47.72± 5.95)ng/L〕 ,尿为 ( 2 3.72± 5.18)ng/L〔对照组 ( 18.55± 2 .83)ng/L〕 ;CGRP质量浓度血浆为 ( 90 .0 1± 2 9.77)ng/L〔对照组( 51.73± 15.2 2 )ng/L〕 ,尿为 ( 58.33± 2 2 .53)ng/L〔对照组 ( 2 6 .2 1± 7.2 2 )ng/L〕 ;均明显高于对照组 (P <0 .0 1)。血、尿中ET呈正相关 (r =0 .34 1,P <0 .0 5)。血、尿中CGRP呈显著正相关 (r=0 .516 ,P <0 .0 0 1)。血ET与CGRP呈显著正相关 (r =0 .573,P <0 .0 0 1) ,与GFR呈显著负相关 (r =- 0 .593,P <0 .0 0 1) ;尿ET与GFR呈显著负相关(r=- 0 .330 ,P <0 .0 1)。血、尿CGRP与GFR呈显著正相关 (r分别为 0 .392、0 .4 12 ,P均 <0 .0 1)。提示 :慢性肾炎患者病程发展与血及尿中ET。The aim was to observe the change of endothelin(ET) and calcitonin gene—re lated peptide (CGR P) in patients suffering chronic nephritis in the decompensated stage of renal d ysfunction and their relationship with glomerular filtration rate (GFR) and in o rde r to elucidate the significace of their changes. The plasmer and urine ET and CG RP levels were assessed with radioimmunoassay in 36 patients with chronic nephri tis and correlation analysis. The plasma and urine ET were (72.45±20.65)ng/L, (23.72±5.18)ng/L, CGRP were (90.01±29.77)ng/L, (58.33±22.53)ng/L, respecti vely in chronic nephritis, they were significantly higher than those in normal c ontrols( P <0.01). Positive correlation was found between plasma and urine ET ( r =0. 341, P <0.05), CGRP( r =0.516, P < 0.001 ). Positive correlation exist ed between p lasma ET and CGRP( r =0.573, P <0.001). Negative correlation lied in betwe en ET in p lasma and urine and GFR( r =-0.593, P <0.001. r =-0.330, P <0.01). Po sitive correlation existed between CGRP and GFR in plasma and urine( r =0.392 、0.412, P <0.01). In patients with chronic nephritis in the decompensated stage of r enal dysfunction, the change of ET and CGRP in plasma and urine may play a role in progress in some degree.

关 键 词：慢性肾炎 内皮素 降钙素 基因相关肽 肾小球滤过率 

分 类 号：R692.31[医药卫生—泌尿科学]