脊髓损伤中枢性疼痛大鼠损伤节段上WDR神经元的电生理变化  

Electrophysiological Changes of WDR Neurons in Spinal Cord Above Injury Plane in Rats with Chronic Central Pain Following Spinal Cord Injury

作　　者：赵晓东[1] 郑泓溶[2] 赵峰[3] 熊开宇[2] 

机构地区：[1]河北医科大学附属第二医院外科 [2]北京体育大学运动生理学教研室 [3]首都医科大学环境卫生与劳动卫生教研室

出　　处：《首都医科大学学报》2004年第1期12-14,共3页Journal of Capital Medical University

基　　金：北京市自然科学基金 (7982 0 6);北京市青年科技骨干培养基金资助项目

摘　　要：为研究脊髓损伤后慢性中枢性疼痛 (CCP)的发生机制 ,将大鼠以重物坠落法造成脊髓损伤CCP模型 ,记录损伤平面上广动力范围 (WDR)神经元诱发放电的变化 ,并以正常大鼠为对照进行比较。发现 :具有CCP大鼠的WDR神经元的诱发电位晚成分的放电阈值、潜伏期、放电频率、放电数与对照相比有非常显著性差异 (P <0 .0 1) ;早成分除放电数有非常显著性差异 (P <0 .0 1)外 ,其他指标与对照组相比无显著差异。提示To investigate the mechanism of chronic central pain(CCP) after spinal cord inju ry(SCI), the model of CCP was made by weight dropping, then recording the evoked potential of wide dynamic rang (WDR)neurons in spinal cord above the lesion plan e. Compared with the normal rats, the number of early discharges of stimulation -evoked responses significantly decreased. As to the late discharges of stimula tion-evoked responses, respectively the threshold decreased, the latent per iod was shortened, the frequency and the number increased significantly compared with the normal rats. The result suggests that the high excitability of WD R neurons in center above the injury plane may be the reason of CCP after SCI.

关 键 词：脊髓损伤 中枢性疼痛 大鼠 损伤 WDR神经元 电生理 

分 类 号：R651.2[医药卫生—外科学]