SARS定点医院工作人员白细胞及红细胞天然免疫黏附功能的变化  

Changes of white blood cells count and erythrocyte innate immune adhesion function in staff of SARS hospital

作　　者：王海滨[1] 刘西秦[2] 郑晖[2] 李进[2] 李庆虹[2] 姜平[1] 赵敬昌[2] 吕宏宇[2] 杨艳[2] 刘振红[1] 鞠连才[1] 

机构地区：[1]解放军第302医院临床检验中心,北京100039 [2]解放军第302医院医务部

出　　处：《第二军医大学学报》2004年第3期265-267,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金"防治 SARS紧急研究"项目(30 340 0 0 9) ;国家高新技术发展规划 (863)课题 (2 0 0 3AA2 0 831 7)

摘　　要：目的 :研究 SARS定点医院不同岗位工作人员白细胞分类及红细胞天然免疫黏附功能 (erythrocyte innate imm uneadhesion function,EIIAF)的变化 ,了解 SARS定点医院医务人员生理机能的变化。方法 :将研究对象分成 5组 ,分别为 SARS定点医院门诊检验人员组、SARS一线人员组、非 SARS病区人员组、医院机关人员组以及院外对照组。对以上各组人员分别进行白细胞分类及 EIIAF测定。SARS特异性 Ig G抗体的检测采用 EL ISA法。结果 :SARS定点医院各组人员的白细胞总数显著高于院外对照组 (P<0 .0 5 ,P<0 .0 1 ) ;SARS一线人员和门诊检验人员的 EIIAF显著低于非 SARS病区人员和机关人员(P<0 .0 1 ) ,其中有 37.5 %的 SARS一线人员的 EIIAF低于正常人平均水平。 6位参与重症 SARS抢救而无显性发病的医务人员 EIIAF全部处于高表达水平 (与正常人群平均水平比较 ,P<0 .0 5 )。结论 :SARS环境中的工作人员机体处于应激状态 ,与 SARS密切接触的一线人员机体存在免疫清除过程 ,亚健康状态可能是 SARS相关医务人员易感的重要原因之一。Objective:To study the changes of the white blood cells(WBC) and erythrocytes innate immune adhesion function(EIIAF) in staff in SARS hospitals, and to investigate their physiology changes. Methods: Rapid assay of EIIAF and WBC counts were performed by Sysmex K4500 in 5 groups:staff in Lab and outpatient service,frontline SARS combat, non SARS areas, office,and the controls outside the SARS hospital. Results: The number of WBC in all groups in SARS hospital were significantly higher than that of controls outside SARS hospital( P <0.05, P <0.01).The activity of erythrocytes innate immune adhering antigen in doctors and nurses worked in SARS cells was significantly lower than those worked in non SARS cells and offices( P <0.01). Totally 37.5% of doctors and nurses in SARS cells had a lower EIIAF than those of normal individuals. The EIIAF in 6 staff members worked in severe SARS emergency were all at high levels compared with healthy individual ( P <0.05). Conclusion: Staff worked in SARS cells may suffer immune clearance; the sub healthy conditions may be the causes of SARS infection in doctors or nurses.

关 键 词：SARS 定点医院 工作人员 白细胞 红细胞天然免疫黏附功能 

分 类 号：R563.1[医药卫生—呼吸系统]