月见草油自乳化制剂处方研究  

Self-emulsifying preparation of evening primrose oil

作　　者：李国栋[1] 范伟[2] 陆国浩[2] 高申[1] 张勇[2] 

机构地区：[1]第二军医大学药学院药剂学教研室,上海200433 [2]第二军医大学药学院

出　　处：《第二军医大学学报》2004年第3期320-322,共3页Academic Journal of Second Military Medical University

基　　金：上海市自然科学基金 (0 3ZR1 4 0 30 )

摘　　要：目的 :研究月见草油自乳化制剂 ,探求其最佳处方配比。 方法 :通过溶解度实验、正交筛选和三相图的绘制 ,以形成乳剂的乳化程度、未乳化油的体积和所得乳滴粒径的大小为指标 ,对月见草油处方中的药物、非离子表面活性剂、潜溶剂的用量比例进行筛选 ,寻找出最佳的搭配和处方配比。结果 :在月见草油的自乳化制剂处方中 ,当非离子表面活性剂选用吐温 - 85、潜溶剂选用丙二醇时 ,可以获得较好的乳化效果。 结论 :月见草油自乳化的最佳处方比例为月见草油∶吐温 - 85∶丙二醇 =5∶ 7∶Objective:To search for the optimum formula for the self emulsification of evening primrose oil. Methods: Through solubility experiment, orthogonal screen and drawing phase diagram, taking the degree of emulsifying, the volume of the rest oil and emulsion particle size as parameters,the oil, non ionic surfactant and flux for the optimum formulation were screened. Results: In the formulation of evening primrose oil, taking Tween 85 as the non ionic surfactant and propylene glycol as the co surfactant can get the best effect of emulsifying. Conclusion: The optimum formula for self emulsification of evening primrose oil is evening primrose oil, Tween 85 and propylene glycol,with their proportion being 5∶7∶3.

关 键 词：月见草油 自乳化 处方研究 剂型改进 

分 类 号：R944.1[医药卫生—药剂学]