迟发性外伤性颅内血肿凝血、纤溶机能异常的临床研究  

Clinical research on dysfunction of coagulation and fibrinolysis in delayed traumatic intracranial hematoma

作　　者：江野峰[1] 梁庆新[1] 何锦[1] 钟树奇[2] 

机构地区：[1]广东省佛山市中医院神经外科,广东佛山528000 [2]广东省佛山市中医院检验科,广东佛山528000

出　　处：《中华神经医学杂志》2004年第2期132-133,共2页Chinese Journal of Neuromedicine

摘　　要：目的探索凝血、纤溶机能异常在迟发性外伤性颅内血肿形成中的作用及围手术期处理。方法动态测定16例迟发性外伤性颅内血肿患者手术前后和输入冷沉淀和新鲜血浆后血浆中D-二聚体、纤维蛋白降解产物和纤维蛋白原水平的变化,并设对照组进行比较。结果迟发性外伤性颅内血肿患者血浆中D-二聚体含量,高于对照组。输入冷沉淀和新鲜血浆后血浆中D-二聚体含量下降,纤维蛋白原水平升高。结论迟发性外伤性颅内血肿的形成,与患者凝血纤溶机能异常有关。输入冷沉淀和新鲜血浆有助于患者凝血纤溶机能的改善。Objective To explore the role of abnormal coagulation and flbrinolysis function in patients with delayed traumatic intracranial hematoma (DTIH) and the perioperative management. Methods The levels of the serum D-Dimer, fibrin degradation product (FDP), and fribinogen (Fb) in 16 DTIH cases as operated group and another 30 cases with no DTIH with matched sex and age as control group were dynamically measured before and after operation, after transfusion of fresh serum and cryoprecipitates respectively. The outcome was comparatively analyzed with SAS software. Results The level of the serum D-Dimer in all the DTIH patients was higher than that of control group. After the transfusion of fresh serum and cryoprecipitates, D -Dimer went down and Fb grew higher in operated group but the controls remained unchanged. Conclusion The formation of DTIH is related to the dysfunction of coagulation and flbrinolysis. The transfusion of fresh serum and cryoprecipitates helps the improvement of the abnormal coagulofibrinolytic function.

关 键 词：迟发性外伤性颅内血肿 血肿凝血 纤溶机能异常 围手术期 DTIH 

分 类 号：R651.15[医药卫生—外科学]