细胞替代治疗与神经干细胞  

Cell replacement therapy and neural stem cells

作　　者：金澎 [1] 徐如祥 [2] 姜晓丹 [2] 

机构地区：[1]珠江医院神经外科 [2]第一军医大学珠江医院神经外科,全军神经医学研究所,广东,广州,510282

出　　处：《中华神经医学杂志》2004年第2期146-150,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(3027047);军队(01Z054);广东省科技厅[No 粤科基办(2000)25;粤财企(2001)367]重大科技项目基金资助

摘　　要：细胞替代治疗是重建受损神经系统的组织结构,恢复神经系统功能的一种有效策略。以往人们把细胞替代的研究重点放在胎脑细胞移植上,而且在治疗神经系统外伤和变性疾病的研究中获得了成功的经验,但是供体细胞来源的有限性及使用人体胚胎所面临的伦理道德的争议限制了它在临床治疗中的进一步应用。神经干细胞研究的发展为神经系统疾病的细胞替代治疗提供了一种新的途径。本文在总结细胞替代策略已有成果的基础上,着重对神经干细胞在细胞替代治疗方面的特点进行综述。Cell replacement therapy is an effective strategy for organization reconstruction and function recovery of injured nervous system. Fetal brain cells, which have been proven to be successful in substituting the damaged neural cells and treating neurodegenerations, were considered as the focus of cell replacement therapy. However, significant constraints such as donor resources and ethical problems associated with the use of embryonic human tissue from abortions have hampered its further use in clinic. Neural stem cells provide a new approach for cell replacement therapy in nervous system diseases. This article discusses the achievements of research on cell replacement therapy obtained so far, and meanwhile further elucidating the properties of neural stem cells in cell replacement therapy.

关 键 词：细胞替代治疗 神经干细胞 神经系统 细胞移植 神经外科 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]