奎硫平与氯氮平治疗精神分裂症的对照研究  被引量:1

Comparative study on therapy of schizophrenia with quetiapine and clozaping

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作  者:沈建华[1] 冯志颖[1] 郭杰[1] 王伟[1] 王正午[1] 

机构地区:[1]天津市安定医院,天津300074

出  处:《天津药学》2004年第1期38-39,共2页Tianjin Pharmacy

摘  要:目的 :探讨奎硫平 (思瑞康 )治疗精神分裂症的疗效和安全性 ,以氯氮平为对照进行研究。方法 :对 80例精神分裂症患者分为两组进行 8周观察 ,奎硫平研究组和氯氮平对照组各 4 0例 ,于治疗前和治疗后每周进行 BPRS和 TESS评定。结果 :奎硫平组和氯氮平组之间疗效无显著性差异 ,但奎硫平组不良反应明显少于氯氮平组 ,主要有轻度头昏、低血压、食欲减退等。结论Object: To explore the efficacy and safety of quetiapine treating schizophrenia with clozapine as control study. Methods: 80 cases with schizophrenia were randomly divided into experimental (quetiapine) and control (cloazpine) group Each group had 40 cases and the study lasted for 8 weeks. BPRS and TESS scales were used respectively to evaluate the effectiveness and safety before treatment and at the end of every week after treatment. Results: There were no significant differences in effectiveness between the two groups. The main side effects in quetiapine group were mild dizziness, hypotension and decreased food appetite etc. Conclusion: Quetiapine was an effective and safe neuroleptics.

关 键 词:精神分裂症 奎硫平 氯氮平 

分 类 号:R971.4[医药卫生—药品]

 

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