青蒿油纳米脂质体制剂对痤疮致病菌的抑制作用  

Inhibitory Effect of Nasometer Liposomes of Artemisia Oil on Pathogenic Bacteria of Acne

作　　者：李向阳[1] 朱宇同[1] 王艳芳[2] 符林春[1] 黄真炎[3] 黄进梅[4] 邢基斯[5] 王冠军[5] 

机构地区：[1]广州中医药大学热带医学研究所,广州510405 [2]广州中医药大学,2000级硕士广州510405 [3]广州中医药大学电镜室,广州510405 [4]广东省皮肤病防治研究所,广州510500 [5]广州中医药大学第一临床学院中医系98级,广州510405

出　　处：《广州中医药大学学报》2004年第2期122-124,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广州中医药大学健桥基金(编号:K6R02008)

摘　　要：【目的】比较青蒿油纳米脂质体和青蒿油的体外抑菌作用。【方法】通过制备不同浓度的青蒿油和青蒿油纳米脂质体的药物培养基,分别观察其对痤疮丙酸杆菌、金黄色葡萄球菌和糠秕孢子菌的抑菌效应。【结果】青蒿油纳米脂质体的最低有效浓度为0.648mg/L,而阳性对照药青蒿油的最低有效浓度为6.48mg/L,在0.648mg/L浓度时仅对金黄色葡萄球菌有抑制作用。【结论】通过纳米脂质体的制备工艺,可以增强青蒿油的抑菌疗效,减少用药量。[Objective] To compare the in-vitro antibacterial action of artemisia oil and artemisia-oil nasometer liposomes. [Methods] Various culture medium containing different concentrations of artemisia oil or artemisia-oil nasometer liposomes was prepared to observe the effects of artemisia oil and artemisia-oil nasometer liposomes on acne propionate bacillus, staphylococcus aureus and sporidium furfur. [Results] The minimum effective concentration of artemisia-oil nasometer liposomes was 0.648mg/L and that of artemisia oil was 6.48mg/L. Artemisia oil at the concentration of 0.648mg/L had inhibitory effect only on staphylococcus aureus. [Conclusion] The preparation of nasometer liposomes can increase the effect of artemisia oil and decrease its dose.

关 键 词：青蒿油纳米脂质体制剂 痤疮致病菌 抑制作用 中药 

分 类 号：R285.5[医药卫生—中药学]