补肾活血中药对子宫内膜异位症的影响  

Experimental Study of Effect of Kidney-Invigorating & Blood-Activating Herbs on Endometriosis

作　　者：沈洪沁[1] 洪波[1] 张薇[2] 邹移海[2] 关慧云[1] 魏龙星[1] 

机构地区：[1]广州市中医院,广州510130 [2]广州中医药大学实验动物中心,广州510405

出　　处：《广州中医药大学学报》2004年第2期143-147,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：省中医管理局项目(编号:98434)

摘　　要：【目的】观察补肾调经汤内服加活血散结栓塞肛对子宫内膜异位症(简称内异症)体液免疫及异位子宫内膜的影响。【方法】SD大鼠130只,随机分为10组,分别为正常对照组、模型组、丹那唑阳性对照组及不同剂量补肾调经汤灌胃或加用和单独使用活血散结栓塞肛治疗7个组。除正常对照组外,其他组均复制大鼠子宫内膜异位症模型,然后分别给药,治疗4周后检测血清IgG、IgM、IgA抗体和补体C_3、C_4及谷丙转氨酶(ALT)水平,进行胸腺、卵巢、子宫、异位移植物及肝、肾组织的病理学检查。【结果】大鼠内异症模型手术4周后,异位的子宫内膜生长良好,IgG、C_3水平升高,IgM下降,子宫、卵巢增大;中药及丹那唑治疗后均可使异位的内膜萎缩,3倍人用剂量中药灌胃加塞肛或5倍量组IgG值下降,5倍量中药塞肛或加灌胃组C_3值下降,5倍量中药灌胃加塞肛组子宫和卵巢缩小;丹那唑对模型动物的性周期有抑制作用,而中药组均无此作用;各给药组均对大鼠的ALT无明显影响。【结论】补肾调经汤内服加活血散结栓塞肛可使内异症模型大鼠的子宫内膜萎缩,改善其体液免疫功能。[Objective] To study the influence on humoral immunity and ectopic endometrium by infusion of Bushen Tiaojing Decoction (BTD) with the Huoxue Sanjie Suppository (HSS) in anus. [Methods] One hundred and thirty SD rats were allocated to ten groups: normal control (A), model (B), normal dose of HSS (C), normal dose of BTD with HSS (D), 3 doses of BTD (E), 3 doses of BTD with HSS (F), 5 doses of BTD (G), 5 doses of HSS (H), 5 doses of BTD with HSS (I), and Danazol (J) groups. The endometriosis (EM) rats were modeled by endometrium implantation in all groups except those in Group A. Four weeks after the treatment, the contents of immunoglobulin (IgG、IgM、IgA), C_3, C_4 and ALT were tested, and histomorphomological analysis of the thymus, ovary, uterus, EM implants, liver and kidney were performed. [Results] Four weeks after EM implantation, the ectopic endometria were growing well, IgG and C_3 increased, but IgM decreased, and the uterus and ovary significantly enlarged. With the treatment of BTD and HSS or Danazol, the ectopic endometria were atrophied. In Groups F and G, IgG decreased; in Groups H and I, C_3 decreased, and uterus and ovary shrunk in Group I. Danazol can help to prolong the sexual cycle, while BTD and HSS can not. In all the medication groups, no obvious difference was found in ALT of the rats. [Conclusion] Oral administration of BTD with HSS can cause endometrial atrophy and improve humoral immunity in model rats.

关 键 词：补肾活血中药 子宫内膜异位症 免疫学 病理学 中医药疗法 

分 类 号：R271.917.1[医药卫生—中西医结合]