5.7-双羟色胺对关节痛大鼠电针镇痛及中枢P物质含量的影响  

INFLUENCE OF 5.7-DIHYDROXYTRYPTAMINE ON ELECTRO-ACUPUNCTURE ANALGESIA AND SUBSTANCE P LEVEL IN CENTRAL NERVOUS SYSTEM OF THE ARTHRALGIC RATS

作　　者：崔仁麟[1] 赵飞跃[1] 马春红[1] 田宇瑛[1] 蔡红[1] 朱丽霞[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》1992年第3期183-185,共3页Acupuncture Research

摘　　要：以前的实验证明,电针镇痛同时提高脑干5-羟色胺(5-HT)水平可能是通过5-HT能下行抑制起作用。大鼠给予对氯苯丙氨酸(PCPA)。The relation between clectroacupuncture (EA)analgesia (A)and substance P (SP)level in the brain stem(BS) and lumbar sp(?)nal cord (LSC) of arthralgic rats was investigated. The rats were divided into three groups:1)5.7-dihydroxytryptamine(5·7-DHT)+EA, 2)vehicle(V)+EA, and 3)5·7-DHT. All the animals were induced arthralgesia by injecting Freund's adjuvant 7 days after cisterna injection of 5·7-DHT or vehicle. The SP level in the BS and LSC was determined by RIA. The results indicated that in V+EA group the EA could prolong tail flick latency by 39.6%, but in other two groups did not. The SP level in LSC of V+EA group (179.1±11.5pmol/g) was higher than that in the 5·7-DHT+EA (135.9+9.3pmol/g)and 5·7-DHT (125.8±10.0 pmol/g) groups. It suggested that both EA and arthralgia could activate the descending 5-HTergic inhibitory system to inhibit the release of SP in LSC, When the 5-HTergic system was destroyedby 5·7-DHT, the EAA was attenuated, and the SP level in LSC was lowered due to its release was decreased by EA and arthralgia.

关 键 词：关节痛 电针镇痛 脑干 P物质 

分 类 号：R245.97[医药卫生—针灸推拿学]