不同频率电针耐受对大鼠脊髓水平阿片肽心血管抑制作用的影响  

EFFECT OF ELECTROACUPUNCTURE TOLERANCE BY DIFFERENT FREQUENCIES ON THE CARDIOVASCULAR INHIBITION OF SPINAL OPIOID PEPTIDES OF THE RATS

作　　者：梅林[1] 朴素芬 韩济生[1] 

机构地区：[1]北京医科大学生理教研室,北京100083

出　　处：《针刺研究》1992年第3期179-182,共4页Acupuncture Research

摘　　要：在针刺镇痛原理的研究中,有资料表明,低频2赫电针引起的镇痛可被甲啡肽抗体对抗,高频100赫电针镇痛可被强啡肽抗体对抗,而变频2～15赫电针镇痛既可被甲啡肽抗体、也可被强啡肽抗体对抗,Continuous 6 hour's electroacupuncture(EA) of 2-15Hz or 2Hz applying to both legs of the rats resulted in the electroacupuncture tolerance(ET). Then, we observed:(l)The effect of 2-15Hz ET on the recovery of mean arterial blood pressure(MAP) and heart rate(HR) of rats after hemorrhagic shock) (2) The change in MAP and HR of rats subjected to 2Hz ET after intrathccally(i. t.)administration of DADLE 25μg, a delta opioid agonist. The results showed that, firstly, there was no difference between 2-15Hz ET group and control group in the recovery of MAp and HR after hemorrhagic shock. Secondly, DADLE(25μg)caused almost the same suppression effect both in 2Hz TE group and in control group. These results suggest that unlike the spinal dorsal horn cells (regulating algesia, the spinal lateral horn cells (regulating blood pressure)are insensitive during EA analgesia and can not be made tolerance to continuous EA.

关 键 词：电针 脊髓 阿片肽 心血管 大鼠 

分 类 号：R245.97[医药卫生—针灸推拿学]