大鼠下丘脑室旁核参与针刺镇痛的电生理学观察  

ELECTROPHYSIOLOGICAL OBSERVATION ON THE ROLE OF THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS IN ACUPUNCTURE ANALGESIA

作　　者：韩永勤[1] 印其章[2] 

机构地区：[1]蚌埠医学院 [2]苏州医学院神经生物学研究室,江苏215007

出　　处：《针刺研究》1992年第3期161-165,共5页Acupuncture Research

基　　金：江苏省科委资助项目

摘　　要：近年来研究资料表明,主要调节血压、内分泌和植物性功能的加压素(Vasopressin,VP)也参与痛觉调制。脑室内注射VP可产生明显的镇痛作用,相反。In this experment, the role of PVN in acupuncture analgesia was further investigated with electrophysiological technique. In wistar rats the unit discharge was recorded extracellularly, Noxious stimulation was applied to sciatic nerve, and the electroacupuncture was performed on acupoints 'Zusanli' and 'Sanyinjiao'. Totally eighty-two units were recorded successfully from PVN. 49 units of them reacted to electroacupuncture with excitatory (14), inhiditory (23) or on significant effect (12). Various types of reactions including excitation (12), inhibition (6),excito-inhibition (4) or inhibito-excitation (3) were observed on 43 units during noxious stimulation of sciatic nerve. The remainder 18 units had no significant reaction. After electroacupuncture those units reacting with excitatory effect on noxious stimulation decreased their firing rate, and those with inhibitory effect increased their firing rate. The duration of nociccptive reaction was shortened after electroacupuncture in both types of units. It was suggested that electroacupuncture could influence the activities and decrease the nociceptive reactions of PVN neurons, which might be considered as electrophysiological evidence of the involvement of PVN in acupuncture analgesia.

关 键 词：下丘脑 针刺镇痛 电生理学 

分 类 号：R245－0[医药卫生—针灸推拿学]