孕期接触二硫化碳对子代行为功能影响的初步研究  

Behavioral effects of carbon disulfide exposure on offsprings.

作　　者：孙瑜[1] 梁友信[1] 陈自强[1] 蒋学之[1] 黄磊[1] 

机构地区：[1]上海医科大学劳动卫生教研窒,200032

出　　处：《职业医学》1992年第1期15-18,共4页China Occupational Medicine

摘　　要：本文通过现埸和实验室研究,讨论CS_2对子代的可能影响。结果发现,母鼠于孕6～15天吸入CS_2后,对其子代的行为功能有影响,特别是学习能力的影响在30、155和760mg/m^3的染毒组中均能发现。现埸研究亦发现子女的智力发育受父母接触浓度的影响,而与双亲中哪一方接触关系不大,并且父母接触CS_2的平均浓度高于10mg/m^3将会影响子女的智力发育。Behavioral effects of prenatally exposed to carbon disulfide on offsprings were studied by means of experimental behavioral teratology in rats and epidemiological investigation in children from exposed parents. The results of behavioral teratological tests indicated that some retardations of behavioral development, in particular, the learning ability, were observed in groups of newborn rat prenatally exposed to 30, 155 and 760mg/m^3 from since 6th～15th days of gestation. The results from field investigation indicated that the development of intelligence in children from mother or father or both exposed to CS_2 at level above 10mg/m^3 was significantly less well in comparison to that of the referent group (verbal IQ 105.9 vs 96.1, t=2.79, P<0.01; total IQ 107.4 vs 99.5, t=2.14, P<0.05) in spite of no finding of difference in physical development. In terms of confounding effects the education level of mothers showed a positive influence on the development of children intelligence.

关 键 词：智力 子代 行为畸胎学 二硫化碳 

分 类 号：R598.102[医药卫生—内科学]