醋酸铅对甲状腺损害的实验研究  

Damage effect of lead acetate on thyroid of rhesus monkeys.

作　　者：梁华[1] 闭中强[1] 樊建康[1] 杨洁芳 汤俊豪[1] 

机构地区：[1]广西壮族自治区职业病防治研究所,南宁市530021

出　　处：《职业医学》1992年第5期263-264,共2页China Occupational Medicine

摘　　要：本文应用恒河猴,对醋酸铅致甲状腺的毒性作用及其机制进行了实验观察。实验结果表明,染毒后动物血铅和δ-ALAD水平显著改变(P<0.05或<0.01),TSH水平明显高于对照组,而T_3水平低于对照组(P<0.05或<0.01),且呈良好的剂量一反应关系。甲状腺铅含量高剂量组明显高于对照组,低剂量组与对照组接近。血铅水平与甲状腺铅含量之间呈明显正相关(r=0.954,P<0.01).组织病理学检查见高剂量组甲状腺滤泡上皮呈高柱状,数目增多。提示在5～15mg/kg剂量的水平之下,铅可以造成甲状腺功能损害,其损害机制可能是铅在甲状腺内竞争与碘结合蛋白结合,而引起碘不足。The damage effect of lead acetate on thyroid of rhesus monkeys was reported. Monkeys, adult, male and weighing 5.0～9.0kg,were divided into three groups. Two groups were treated by nasal feeding with lead at the doses of 5 and 15 mg/kg, respectively, one time a day and five times a week for 45 days. The control group was treated deionized water instead. The experimental results revealed that the levels of PbB and δ-ALAD in the exposed groups were higher than that of the controls (P<0.05 or 0.01). In both exposed groups, the levels of TSH were higher and the levels of T_3 were lower than that of the controls, with rather good dose-response relationship. The contents of Pb-thyroid in the controls, 5 and 15 mg/kg group were 2.81±1.30, 3.25±0.92 and 15.94±12.45 nmol/g tissue,respectively. Histological examination of the thyroid in the exposed groups showed that the follicular epithelial cells were high-column like and the number of the cells increased.These results suggested that the lead at the doses of 5～15 mg/kg could directly injure the thyroid.

关 键 词：醋酸铅 甲状腺毒性 恒河猴 

分 类 号：R598.11[医药卫生—内科学]