大鼠海马CA3区神经元突触的老龄性改变  

Changes of synapse in hippocampus CA3 neurons in aged rats

作　　者：赖红[1] 马萍[2] 高杰[1] 王铁民[1] 包峰[1] 吕永利[1] 

机构地区：[1]中国医科大学脑研究所神经解剖研究室,辽宁沈阳110001 [2]中国医科大学附属第一医院肿瘤研究所第二研究室,辽宁沈阳110001

出　　处：《中国医科大学学报》2004年第2期102-103,109,共3页Journal of China Medical University

基　　金：辽宁省自然科学基金资助项目 ( 5 190 81)

摘　　要：目的 :观察老龄大鼠海马CA3区神经元突触超微结构的改变 ,探讨老龄动物海马学习记忆功能减退的形态学基础。方法 :应用透射电镜技术 ,观察青年组 (3～ 5月龄 )和老龄组 (2 4～ 2 6月龄 )Wistar大鼠海马神经元的超微结构。结果 :老龄组海马CA3区神经元的主要变化 :突触连接缩短或间断、突触前后膜融合 ;突触小胞大量集聚、小胞大小不等 ;树突棘内棘器远离突触后膜 ,其扁平小囊增多并扩张。结论 :老龄大鼠海马CA3区神经元突触发生了明显的变性改变 ,这可能是导致学习记忆障碍的形态学基础。Objective: To observe the synapse changes of the neurons in hippocampus CA3 of aged rat and to provide the morphological basis for the mechanism of learning and memory in aged rats. Methods: The synaptic changes of hippocampus neurons in young rats ( 3 to 5 months old) and in aged rats (24 to 26 months old) were observed with electron microscopy. Results: The synaptic connection in aged rats were shortening or discontinuing; fusion of presynaptic and postsynaptic membranes could be observed. The synaptic vesicles in aged rats increased, the size were different, and accumulation presented. The spine apparatus were far away from postsynaptic membrane; the flat vesicles of the spine apparatus were expanding and increased in number. Conclusion: The neurons and synapses of hippocampus CA3 in aged rats presented degenerative changes. The results provided morphological basis for decreasing of learning and memory functions in aged rats.

关 键 词：海马CA3区 突触 老龄大鼠 棘器 神经元 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]