尿微量白蛋白、脉压及肾小球滤过率在高血压病早期肾损伤中的意义  

Significance of microalbuminuria, pulse pressure, and glomerular filtration rate in essential hypertensive subjects with early renal injury

作　　者：李梦[1] 胡健[1] 方慧娟[1] 樊新[2] 吴星[1] 

机构地区：[1]中国医科大学附属第一医院循环内科,辽宁沈阳110001 [2]中国医科大学附属第一医院放射治疗科,辽宁沈阳110001

出　　处：《中国医科大学学报》2004年第2期167-169,共3页Journal of China Medical University

摘　　要：目的 :探讨高血压病尿微量白蛋白 (MA)与脉压、肾小球滤过率 (GFR)等指标间的相关性。方法 :70例高血压病患者分成正常白蛋白尿组和微量白蛋白尿组 ,采用放射免疫法测定尿白蛋白排泄率 (UAER) ,采用99mTc DTPA肾动态显像测定GFR ,同时测定血清肌酐、血压等。结果 :微量白蛋白尿患者的脉压、收缩压明显升高、GFR显著下降。UAER与脉压、收缩压、血清肌酐、体重指数 (BMI)分别呈正相关 ,与GFR呈负相关。脉压和GFR是与UAER显著相关的因素。结论 :MA与脉压、GFR等指标之间存在显著相关性是高血压病早期肾功能损伤的重要因素 ,对脉压增大的高血压病患者进行适时治疗是保护肾功能的有益措施。Objective: To examine the association between microalbuminuria(MA)and pulse pressure(PP), glomerular filtration rate(GFR)in essential hypertensive subjects. Methods: Seventy patients with hypertension were divided into 2 groups: normoalbuminuria and microalbuminuria group. Urinary albumin excretion rate (UAER)was detected by using radioimmunoassay and GFR was determined by using 99m Tc-DTPA. Serum creatinine (SCr), blood pressure, and other factors were also measured. Results: Patients with microalbuminuria were significantly characterized by higher PP, systolic blood pressure (SBP), and lower GFR. Evaluation of bivariate correlation indicated that UAER was positively correlated with PP, SBP, SCr, BMI, and negatively correlated with GFR. Multiple backward regression analysis showed PP and GFR were significantly related to UAER. Conclusion: The significant correlation between PP, GFR, and MA is important factor in hypertensive patients with early renal injury. Preventive treatment should be beneficial for protecting renal function in hypertensive subjects with wide PP.

关 键 词：高血压病 微量白蛋白 脉压 肾小球滤过率 

分 类 号：R544.1[医药卫生—心血管疾病]