红花中核黄素及其降解产物  

Riboflavin and its degradation product from Carthamus tinctorius

作　　者：李锋[1] 何直昇[1] 叶阳[1] 

机构地区：[1]中国科学院上海生命科学研究院上海药物研究所新药研究国家重点实验室,上海201203

出　　处：《中草药》2004年第3期247-249,共3页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目 (2 963 2 0 5 0 )

摘　　要：目的　为进一步揭示红花生理活性的化学物质基础 ,开发其活性成分。方法　对其水溶性部分进行了系统的研究。经过大孔树脂、硅胶、聚酰胺和 Sephadex L H- 2 0反复柱色谱分得了 3个化合物。结果　通过 1D,2 D NMR,ESIMS等波谱测定结合文献调查 ,确定了结构。结论　核苷、核黄素及其降解产物首次从该植物中分得 ,核黄素是人体内黄酶的一种辅酶 ,在人体内有着重要的生理功能 ;化合物 具有很好的降压活性。Object To carry out a systematic study on the chemical constituents of Carthamus tinctorius L. In order to reveal pharmacological active compounds for their further development. Methods Three constituents were separated by macroporous resin, silica gel, polyamide, Sephadex LH-20 and spectral analysis. Results The structures were elucidated by spectroscopic means including 1D, 2D NMR and ESI-MS; they are 1-ribityl-2, 3-diketo-1, 2, 3, 4-tetrahydro-6, 7-dimethyl-quinoxaline (Ⅰ), riboflavin (Ⅱ), and uracil-ribofuranose (Ⅲ). Conclusion Compounds Ⅰ-Ⅲ are isolated from C. tinctorius for the first time. Compound Ⅱ is a very important coenzyme for our bodies. It has been found that compound Ⅰ has the property of lowering the blood pressure of anesthetized dogs when administered in travenously.

关 键 词：红花 菊科 核黄素 核苷 

分 类 号：R284.1[医药卫生—中药学]