Novel and Convenient Approach to Synthesis of AZT/d4T H-phosphonates  

作　　者：林长学 付华 涂光忠 赵玉芬 

机构地区：[1]Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China [2]Beijing Institute of Microchemistry, Beijing 100091, China

出　　处：《Chinese Journal of Chemistry》2004年第3期225-227,共3页中国化学（英文版）

基　　金：Project supported by Excellent Dissertation Foundation by the Chinese Ministry of Education (No. 200222).

摘　　要：A convenient, efficient and general method has been developed for synthesis of H-phosphonate mono and diesters of AZT and d4T through one-pot reaction of phosphonic acid with AZT or d4T and different alcohols using pivaloyl chloride as condensing agent under mild conditions.A convenient, efficient and general method has been developed for synthesis of H-phosphonate mono and diesters of AZT and d4T through one-pot reaction of phosphonic acid with AZT or d4T and different alcohols using pivaloyl chloride as condensing agent under mild conditions.

关 键 词：H-PHOSPHONATE AZT d4T phosphonic acid pivaloyl chloride 

分 类 号：O613[理学—无机化学]