Studies on microdeletion of genes relevant to spermatoge nesis in infertile men  

作　　者：Hui-BinZhu JunLu Li-NanCheng Yin-KunLiu 

机构地区：[1]ShanghaiInstituteofFamilyPlanningTechnicalInstruction,Shanghai200030,China

出　　处：《Asian Journal of Andrology》2004年第1期66-66,共1页亚洲男性学杂志（英文版）

摘　　要：Objective: To study the relationship between relevant gene micro-deletion and spermatogenesis in infertile men. Methods: To analyze the relevant genes of the Y-chromosome and the karyotype of peripheral blood chromosome in 149 azoospermic/sever oligo-spermic infertile men and 100 normal controls by multipolymerase chain reaction (PCR). Results: Microdeletions in different gene segments of the Y-chromosome were present in 11 cases of the infertile group (7.38 %). No microdeletion in the corresponding areas was found in the controls. The incidence of abnormal karyotype in the infertile group was 14.09 % and in the controls, 2 %. In the 11 infertiles with microdeletion in different gene segments, only one had abnormal karyotype, indicating no relativity between the two. Conclusion: Microdeletion of Y-chromosome may be an important cause of male infertility.

关 键 词：male infertility Y-CHROMOSOME multipolymerase chain reaction azoospermia factor 

分 类 号：R698.2[医药卫生—泌尿科学]