芦荟及其复方制剂对衰老小鼠脂质过氧化及白介素水平的影响  

The Effects of Aloe and Its Compound on Lipid Peroxidation and Certain Cytokines of Aging Mice

作　　者：王忠[1] 谷顺才[1] 韩艳丽[1] 肖爱珍[1] 辛益妹[1] 郝爱功[1] 齐颖[1] 程杰[1] 郑伟[1] 

机构地区：[1]中国人民解放军空军航空医学研究所,北京100036

出　　处：《解放军药学学报》2004年第1期8-10,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的　观察芦荟及其复方制剂在抗脂质过氧化、调节免疫因子方面的抗衰老作用 ,为芦荟在老年医学中应用及发掘抗衰老药物提供依据。方法　二级昆明种小白鼠 4 8只 ,随机分为 4组 ,三个衰老组用D 半乳糖法造衰老模型 ,其中两个试验组分别灌胃芦荟液和复方芦荟液 ,衰老模型对照组和正常对照组均灌胃等量 0 .9%NaCl溶液。用药 2 8d后 ,测全血MDA含量、SOD、GSH -Px活性及血清IL 1、IL 6、IL 8水平。结果　衰老模型组与正常对照组比较MDA含量明显升高 ,SOD、GSH -Px活性和血清IL 1、IL 6、IL 8水平降低 ,且体重减轻。应用芦荟和复方芦荟组则使衰老小鼠上述指标明显恢复 ,与衰老模型组比较 ,差异显著。结论　芦荟及其复方制剂在对衰老动物实验模型的应用中有抗脂质过氧化 ,增强自由基清除以及升高已降低的IL 1、IL 6、ILAim To observe the anti-aging effects of aloe and its compound on anti-lipid peroxidation and regulating certain cytokines so as to explore its potential application in geriatrics as an anti-aging drug.Methods Forty-eight Kunming mice were randomly divided into four groups.The three aging-model groups were made by D-galactose,of which two groups were gavaged with pure aloe liquid and its compound respectively.The groups of aging control and normal control were gavaged with equal amount of 0.9% NaCl solution.The aloe and its compound were given to the mice daily for 28 days.The concentration of malon dialdehyde (MDA),the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood and the levels of IL-1?IL-6?IL-8 in serum were examined.Results Compared to the normal control,the aging mice showed significant increase in the concentrations of MDA in blood and significant decrease in the activities of SOD,GSH-Px in blood and the levels of IL-1?IL-6?IL-8 in serum as well as weight loss.The aging groups taking aloe and its compound showed significant improvement for the above parameters compared with the group without taking them.The differences were statistically significant.Conclusions Aloe and its compound showed anti-lipid-peroxidation, enhanced elimination of free radicals and increase of reduced IL-1?IL-6?IL-8 levels in experimental aging mice.

关 键 词：芦荟 过氧化脂质 自由基 白介素IL-1、IL-6、IL-8 延缓衰老 

分 类 号：R286.79[医药卫生—中药学] R285.5[医药卫生—中医学]