扎来普隆胶囊的人体药代动力学研究  

Pharmacokinetics of Zaleplon Capsules in Chinese Healthy Volunteers

作　　者：温预关[1] 马崔[1] 邱畅[1] 侯静[1] 陆欣乔[1] 

机构地区：[1]广州市脑科医院国家药品临床研究基地,广东广州510370

出　　处：《解放军药学学报》2004年第1期24-26,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的　研究国产扎来普隆胶囊在中国人体内的药代动力学特征。方法　 2 0名健康志愿者单剂量口服 15mg扎来普隆胶囊 ,采用高效液相色谱法测定血浆中扎来普隆浓度。结果　扎来普隆胶囊药 -时曲线符合一房室模型 ,其Cmax　为 (6 1.6 0±16 .71)ng·ml-1;Tmax　为 (0 .99± 0 .2 2 )h ,Ke为 (0 .76± 0 .11)h ,T1/ 2 (ke)　　为 (0 .93± 0 .13)h-1;AUC0 -8为 (12 8.5 9± 2 9.0 2 )ng·ml-1·h-1;AUC0 -∞ 为 (130 .34± 2 9.2 7)ng·ml-1·h-1,与国外文献报道基本一致。Aim To study the pharmacokinetics of zaleplon capsules in Chinese healthy volunteers.Methods 20 male healthy subjects received a single oral dose of 15mg zaleplon capsules.The plasma concentrations of zalepon were determined by an improved HPLC method.Results The main pharmacokinetics parameters of zaleplon were as follow:C max was (61.60±16.71)ng·ml -1;T max was(0.99±0.22)h -1,Ke was(0.76±0.11)h -1,T 1/2(ke) was (0.93±0.13)h;AUC 0-8 was(128.59±29.02)ng·ml -1·h;AUC 0-∞ was (130.34±29.27)ng·ml -1·h.Conclusions The study will offer the parameters of the pharmacokinetics for the clinical application of zaleplon capsules.

关 键 词：扎来普隆胶囊 人体 药代动力学 高效液相色谱法 测定 血药浓度 安眠药 

分 类 号：R971.3[医药卫生—药品] R969.1[医药卫生—药学]