卡维地洛对冠脉成形术后血管内皮功能的影响  

Effect of carvedilol on the coronary vascular endothelial function after percutaneous transluminal coronary angioplasty

作　　者：苏显明[1] 马奕[1] 崔长琮[1] 

机构地区：[1]西安交通大学第一医院老年心血管内科,西安市710061

出　　处：《岭南心血管病杂志》2004年第1期21-23,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的　观察卡维地洛对冠心病患者冠状动脉成形术 (PTCA)术后血管内皮功能的影响并探讨其临床意义。方法　经冠状动脉造影证实有一支或二支以上≥ 70 %狭窄需行PTCA的患者 5 1例 ,随机分成卡维地洛 (金络 )治疗组 2 8例和常规治疗组 2 3例。测定PTCA前后及用药前后外周血内皮素 (ET)及一氧化氮 (NO)含量并进行比较。结果　PTCA术后血中ET较术前增高、NO较术前降低 (P <0 0 5 ) ;卡维地洛组ET较用药前降低、NO较用药前增高 (P <0 0 5 ) ,常规治疗组ET及NO观察 2周均无显著变化 (P >0 0 5 )。结论　卡维地洛可以改善冠脉成形术后血管内皮功能。Objectives To understand the effect of carvedilol on the coronary vascular endothelial function of the patients with coronary heart disease after percutaneous transluminal coronary angioplasty (PTCA). Methods 51 cases, having one or more than two branches narrow (≥70%), were diagnosed by coronary angiography. These patients were divided randomly into carvedilol group (n=28) and control group (n=23) who did not take carvedilol. Endothelin (ET) and nitro dioxide (NO) levels of peripheral blood were measured before and after PTCA, before and after two weeks by taking carvedilol. Results Compared with the ET and NO levels before PTCA, ET were markedly increased and NO were decreased after PTCA (P<0.05); compared with the ET and NO levels before taking carvedilol, ET were decreased and NO were increased after two weeks (P<0.05), but the ET and NO levels of the control group did not change in the period of two weeks observation (P>0.05). Conclusions Carvedilol may improve the coronary vascular endothelial function after PTCA.

关 键 词：卡维地洛 冠状动脉成形术 术后 血管内皮功能 冠状动脉狭窄 一氧化氮 

分 类 号：R654.2[医药卫生—外科学] R972[医药卫生—临床医学]