醌类衍生物全反式合成方法研究进展  

Development on Syntheses of E -Configuration Quinone Derivatives

作　　者：韦自娟[1] 李云政[1] 

机构地区：[1]北京理工大学化工与环境学院,北京100081

出　　处：《化学研究》2004年第1期71-74,共4页Chemical Research

基　　金：国家"863"基金资助课题(715 004 0140).

摘　　要：醌类衍生物是生命体活动中的重要物质,但是醌类衍生物只有其反式异构体才有生理活性,所以如何实现醌类物质的全反式合成,是其合成研究的热点.二十世纪六十年以来,具有生物活性的醌类衍生物合成的研究不断深入,并取得了很大的进展.作者就醌类衍生物的全反式合成做一概述.Quinones play an important role in biosynthesis. They include vitamin K, ubiquinine-10 etc. Quinones are bioactive only when the side chains are in all-( E ) configuration. How to obtain all- E configuration quinones is what scientists have been looking for in the past several decades. Since 1960s, the methods of synthesizing quinone have had a great improvement. The article gives a thorough account about the history ,and gives special emphasis on the synthesis that have been proposed by Ruttimann.

关 键 词：醌类衍生物 全反式合成 生理活性 环戊二烯 有机药物 

分 类 号：TQ463.4[化学工程—制药化工]