异烟腙类衍生物TJU103对人T细胞增殖和细胞因子分泌的影响  

Effects of TJU103 on T lymphocytes proliferation and cytokine production

作　　者：张立成[1] 郭坤元[1] 王燕 

机构地区：[1]第一军医大学珠江医院,广州510282 [2]山东药材技工学校,泰安271000

出　　处：《中国免疫学杂志》2004年第3期178-179,共2页Chinese Journal of Immunology

基　　金：全军医学科学技术研究"十五"计划重点课题 (0 1Z0 2 5 0 )

摘　　要：目的 :探讨异烟腙类衍生物TJU10 3体外对同种异体抗原刺激的T淋巴细胞增殖和细胞因子分泌的影响。方法 :采用MTT法和酶联免疫吸附实验 (ELISA)分别观察了TJU10 3对T细胞增殖和分泌细胞因子的影响。结果 :TJU10 3在 5 0mg/L浓度时 ,能够明显降低HLA半相合供、受者间混合淋巴细胞反应 (MLR)以及肿瘤坏死因子α(TNF α)和γ干扰素 (IFN γ)等细胞因子的分泌 (P <0 0 1)。结论 :TJU10 3能够特异性地与CD4 + T细胞结合 ,降低CD4 + T细胞的增殖和细胞因子分泌。Objective:To investigate the effects of TJU103 on T lymphocytes proliferation and cytokine production in vitro.Methods:MTT and ELISA assays were used respectively to detect the proliferation and the cytokine production of donor T lymphocytes blocked by TJU103.Results:There are significant difference in the inhibition of T-cell proliferation and the cytokine production between groups of with TJU103 or without.Conclusion:TJU103 could significantly inhibit the T-cell proliferation and the cytokine production.

关 键 词：TJU103 T淋巴细胞 增殖 细胞因子 

分 类 号：R392[医药卫生—免疫学]