急性重度CO中毒心肌损害患者高压氧治疗期间血清相关酶的变化及意义  

The change and significance on the contents of serum interrelated kinases in patients with severe acute CO poisoning during the time of hyperbaric oxygen in treating myocardial damage

作　　者：周宏图[1] 袁建国[1] 张雪春[1] 

机构地区：[1]江苏大学附属医院高压氧科,江苏镇江212001

出　　处：《重庆医学》2004年第3期332-333,共2页Chongqing medicine

摘　　要：目的　观察重度急性一氧化碳中毒 (ACOP)后心肌损害患者高压氧 (HBO)治疗期间血清肌酸激酶 (CK)及其心型同工酶 (CK MB)的变化 ,探讨HBO治疗CO中毒心肌损害的机理、疗效以及治疗过程中血清CK、CK MB定量检测的临床意义。方法　对 32例Glasgow评分 3～ 7分的重度ACOP患者分别在HBO治疗 1、3、5、1 0次后测定其血清CK、CK MB含量 ,并对患者进行同步心电图 (ECG)检查。另外在健康体检中随机选取 30例健康人血清标本 ,分别测定其血清CK、CK MB作为对照组。结果　随着HBO治疗次数的增多 ,患者ECG逐渐恢复正常 ,血清CK、CK MB含量显著下降 (P <0 .0 1 )。结论　经HBO治疗 ,重度ACOP患者的心肌损害可以较快地得到恢复。血清CK、CK MB检测结合ECG可以在治疗中动态地了解心肌损害的程度和恢复情况。Objective To observe the change of serum interrelated kinases in patients with severe acute carbon monoxide poisoning(ACOP) during the time of hyperbaric oxygen (HBO) treatment. To investigate the mechanism and the effect of HBO in treating myocardial damage . To probe the regular pattern of creatine kinase(CK) and its isoenzyme(CK MB) during the time of HBO and to evaluate the therapeutic effect of HBO. Methods The consciousness of 32 patients with severe ACOP was assessed with Glasgow scale 3 7,immediately after the 1,3,5,10st time HBO therapy. At the same time, these patients had a ECG examination. There were another 30 healthy volunteers as normal controls, the contents of serum kinases were measured. Results With the HBO treatment time goes up, the patients' ECG return to normal and the contents of serum CK,CK MB were significant decrease( P <0.01). Conclusion The myocardial damage of patients with severe ACOP can return to normal with HBO treatment.

关 键 词：高压氧(HBO) 急性一氧化碳中毒(ACOP) 心肌损害 肌酸激酶(CK) 肌酸激酶心型同工酶(CK-MB) 心电图 (ECG) 

分 类 号：R459.6[医药卫生—治疗学]