我国3省同步大骨节病病例对照调查的对比研究  

A comparative study of case-control investigation of Kaschin-Beck Disease in 3 Chinese provinces

作　　者：丁方羽[1] 王治伦[1] 翟俊民[2] 周扬[1] 陈燕[1] 吴劲[1] 

机构地区：[1]西安交通大学医学院地方病研究所,710061 [2]吉林省地方病第二防治研究所

出　　处：《中国地方病学杂志》2004年第2期150-152,共3页Chinese Jouranl of Endemiology

基　　金：联合国儿童基金会资助项目(GR/84/II/005)

摘　　要：目的对黑龙江、甘肃、陕西3省同步、同内容的大骨节病病例对照调查结果进行对比研究,寻找一致性的致病危险因素。方法3省分别采用统一设计的病例对照调查方法,对大骨节病可疑致病因素进行调查,对调查结果用统一的Logistic程序作多元非条件逐步回归分析。结果3省一致性出现的大骨节病致病危险因素有谷物受真菌毒素污染严重、低硒、卫生条件差。结论大骨节病的致病危险因素可能是环境低硒条件下的粮食真菌毒素中毒。Objective To find the risk factors of Kaschin-Beck Disease, a comparative study had been implemented based on the relative case-control study in Heilongjiang, Gansu and Shaanxi provinces in China. Methods Three synchronous case-control studies had been relatively implemented in these three provinces to investigate the risk factors of Kaschin-Beck disease, the multiple nonconditional stepwise regression had been used to analyze the results. We compared these risk factors that were involved in the pathogeny of Kaschin-Beck disease. Results The severe cereal mycotoxin contamination, selenium-deficiency and poor sanitation condition were three prominent risk factors in the 3 provinces. Conclusions The possible risk factors of Kaschin-Beck disease are cereal mycotoxin contamination accompanied with environment selenium-deficiency.

关 键 词：中国 大骨节病 病例对照调查 KBD 防治工作 

分 类 号：R684[医药卫生—骨科学]