急性心肌梗死病人在血磁疗法前后血浆α-颗粒膜蛋白变化及临床意义  

Clinical significance of the change in GMP-140 level on patients with acute myocardial infarction before and after Blood-magent therapy

作　　者：赵毅[1] 张莉[1] 王领娣[1] 

机构地区：[1]哈尔滨市242医院,150066

出　　处：《航空航天医药》2004年第1期4-5,共2页Aerospace Medicine

摘　　要：目的 :探讨血磁疗法对急性心肌梗死病人血小板活化能力的影响。方法 :3 0例急性心肌梗死病人 ,分别在血磁治疗前 ,第一次治疗后 ,第二次及第三次治疗后采静脉血 ,用酶联免疫吸附双抗体夹心法测定血浆α -颗粒膜蛋白 (GMP -14 0 )的含量。结果 :3 0例病人在血磁疗前血浆GMP -14 0即高于正常对照组 (P <0 .0 1)。第一次治疗后出现显著下降 (P <0 .0 1) ,第二次治疗后和第三次治疗后与治疗前相比继续降低 (P <0 .0 1、P <0 .0 1)。结论 :急性心肌梗死病人存在血小板的活化 ,血磁疗法可以降低血小板的活化能力。Objective: To observe the effect of blood-magent therapy on platelet activity in patients with acute myocardial infarction.Methods: The blood samples of 30 AMI patients were obtained from the vein before and after the first therapy the second therapy and the third therapy. The plasm level of GMP-140 were measured using enzyme linked immunosorbent assay(ELESA).Results: The plasm level of GMP-140(ng/ml) in AMI patients were higher than that of 20 healthy volunteer before the blood-magent therdpy. It decreased after the first blood-magent therapy(p<0.01). It dropped significantly after the second and third therapy (p<0.01,p<0.01).Conclusion: There was platelet activation on patients with AMI, Blood-magent therapy may decreased the platelet activation, the ability of rethrobosis dropped.

关 键 词：急性心肌梗死 血磁疗法 Α-颗粒膜蛋白 

分 类 号：R542.22[医药卫生—心血管疾病]