聚乙二醇/聚己内酯两亲性三嵌段共聚物纳米胶束  

STUDIES ON NANOMICELLES OF POLY(ETHYLENE GLYCOL)/ POLYCAPROLACTONE AMPHIPHILIC TRIBLOCK COPOLYMER

作　　者：邓联东[1] 孙多先[1] 霍建中[2] 靳建洲[1] 董岸杰[1] 

机构地区：[1]天津大学化工学院,天津300072 [2]天津师范大学化学与生命科学学院,天津300074

出　　处：《高分子材料科学与工程》2004年第2期217-219,223,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助课题(30170227)

摘　　要：研究了制备聚乙二醇-b-聚己内酯-b-聚乙二醇两亲性三嵌段共聚物(PECL)纳米胶束的各种影响因素,发现PECL纳米胶束的粒径受制备方法的影响较大,且随着PECL的相对分子质量和混合溶剂中二氯甲烷用量的增大而增大。PECL的临界聚集浓度小于4×10-6mol/L,随着共聚物相对分子质量的增大而减小,纳米分散液的临界聚沉浓度随着PECL中PCL相对分子质量的增加而减小,分散液稳定性下降。The factors of the poly(ethylene glycol)-b-polycaprolactone-b-poly(ethylene glycol) (PECL) nanomicelles were researched. The results show that the size of PECL nanomicelles is largely influenced by the prepared methods and increased upon increasing the molecular weight of PECL and the content of dichloride methane in the mixed solvent. The critical associaton concentrations of PECL are less than 4×10^(-6) mol/L and decreases upon increasing the molecular weight of PECL. The critical flocculation point and the stability of nano-dispersion decreases upon increasing the molecular weight of PCL segment in PECL.

关 键 词：纳米胶束 聚乙二醇 聚己内酯 纳米分散液 PECL 药物 生物利用度 

分 类 号：TB383[一般工业技术—材料科学与工程] TQ46[化学工程—制药化工]