一种相变温度与人体正常体温相近的共聚高分子在水溶液中的自缔合行为  

Self-association of a Thermo-sensitive Copolymer with Transition Temperature Coincident to the Normal Body Temperature of Human Beings in Aqueous Solution

作　　者：杨琥[1] 尹唯斯[1] 王治流[1] 丁延伟[2] 张广照[2] 程镕时[1] 

机构地区：[1]南京大学化学化工学院介观化学教育部重点实验室,南京210093 [2]中国科学技术大学化学物理系,合肥230026

出　　处：《化学学报》2004年第6期610-614,共5页Acta Chimica Sinica

基　　金：国家自然科学基金面上基金 (No.2 0 2 0 4 0 0 4 );国家教育部博士点基金 (No .2 0 0 0 0 2 840 4 )资助项目

摘　　要：以N 异丙基丙烯酰胺和N 异丙基甲基丙烯酰胺为共聚单体 ,合成了一种在水溶液中具有与人体正常体温一致的相转变温度的共聚化合物 .并从团簇理论出发 ,结合粘度数据推出了该共聚物在水中的动态接触浓度 ,利用动态光散射技术研究了这一特殊共聚物在动态接触浓度以上水溶液中的自缔合行为 ,讨论了从动态光散射实验得出的该共聚物的表观流体力学半径大小及分布与浓度的依赖关系 .A special thermosensitive copolymer, which has a lower critical solubility temperature near human body temperature of 37 ℃ in aqueous solution, has been prepared successfully by introducing an appropriate quantity of N-isopropylmethacrylamide monomer randomly into the poly(N-isopropylacrylamide) main chain. The self-association behavior of the copolymer in water has been investigated by Dynamic Laser Light Scattering (DLLS) and viscosity method. When the concentration of the solution is higher than the calculated dynamic contact concentration from cluster theory, the effect of the concentration on the distribution of the hydrodynamic radius from the DLLS results has been discussed fully.

关 键 词：相变温度 温敏性共聚高分子 水溶液 自缔合行为 聚N-异丙基甲基丙烯酰胺 表观流体力学半径 动态接触浓度 团簇理论 动态光散射 粘度 

分 类 号：O631[理学—高分子化学]