大黄复方液体喷雾剂中挥发油微乳与相图的应用  

Study on micro-emulsions of volatile oil in rhubarb of compound liquid spray by triangular phase diagram

作　　者：王新春[1] 侯世祥[2] 阳长明 袁勇[1] 

机构地区：[1]新疆石河子大学医学院附一院,新疆石河子832008 [2]四川大学华西药学院,成都四川610041 [3]国家药品监督管理局新药评审中心,北京100038

出　　处：《中成药》2004年第3期178-181,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :用三元相图法优选大黄复方液体喷雾剂中挥发油形成微乳的最佳处方　方法 :选泊洛沙姆 10 8为乳化剂 ,乙醇为助乳化剂 ,姜黄、金银花挥发油为油相 ,借助三元相图的研究手段确定乳化剂和助乳化剂的最佳用量　结果 :泊洛沙姆 10 8与乙醇量的比为 1∶10 ,处方量挥发油形成微乳 ,稳定分散于制剂中。　结论 :借助三元相图研究中药复方液体制剂中挥发油形成微乳的最佳处方 ,为液体制剂中挥发油的稳定分散问题提供了一条捷径 ;通过微乳增加中药复方制剂中难溶性挥发油类药物的溶解度 ,提高中药复方液体制剂的稳定性。AIM: To optimize the best prescription of micro-emulsions of volatile oil in rhubarb of compound liquid spray by triangular phase diagram METHODS : Poloxamer-108 was used as emulsifiers,absolute alcohol as assistant emulsifiers,volatile oil from Lonicera dasystyla and Curcuma longa as the oil phase,the proportion between the emulsifier and append-emulsifier was established RESULTS : Optimized ratio of Poloxamer-108 and alcohol was 1∶10,the volatile oil in prescription formed micro-emulsions,distributing stably in the spray CONCLUSION : The study of micro-emulsions of volatile oil in compound liquid preparation of traditional Chinese medicine by triangular phase diagram offered a short-cut for resolving its stability. The experiment also suggested that the micro-emulsions could increase solubility of insoluble volatile oil from TCM.

关 键 词：三元相图 挥发油 中药液体喷雾剂 

分 类 号：R944.1[医药卫生—药剂学]