通痹止痛胶囊对免疫功能的影响  

Study on immunosuppressive effect of Tongbizhitong Capsule

作　　者：曹露晔 杜瀛琨[2] 王孝蓉[2] 

机构地区：[1]上海中医大学,上海201203 [2]云南中医学院中药系,云南昆明650200

出　　处：《中成药》2004年第3期218-221,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :探讨通痹止痛胶囊 (川附片、制川乌、桂枝桑枝、姜黄等组成 )对变态反应和部分免疫指标时影响。方法 :观察通痹止痛胶囊对大鼠佐剂型关节炎症反应、对佐剂型关节炎大鼠体内自由基及T淋巴细胞亚群的影响 ,以及对小鼠抗体的生成、Ⅳ型变态反应的影响。结果 :通痹止痛胶囊可减轻佐剂型关节炎大鼠足趾肿胀并可显著抑制Th 及Ts 的数目 ,可降低血清中过高的NO及丙二醛 (MDA)的水平 ,可升高红细胞的超氧化物歧化酶 (SOD)及谷胱甘肽过氧化物酶(GSH PX)的水平。可抑制DTH反应、降低小鼠血清溶血素水平的作用。结论 :可看出通痹止痛胶囊有良好的免疫抑制作用。AIM: To study immunosuppressive effects of Tongbizhitong Capsule. To reveal the anti-inflammatory mechanism of this capsule. METHODS : The anti-inflammatory effect was determined with the adjuvant arthritis models of the rats with adjuvant arthris (AA) paw edema. We also observed the blood oxygen free radican,nitric oxide(NO) with AA. The immunosuppressive effect was determined with T-cell subsets in spleen of rats with AA,serum haemolysin level of mouse,the delayed type hypersensitivity. RESULTS : Tongbizhitong Capsule had remarkable inhibitory effect on carrageenine induced granulation and on the prevention of AA. In the T-cell subsets: low,middle and high dose decreased T_h and high dose inhibited both T_s and T_h preacted mainly on T_h and rendered the decreased ratio of T_h/T_s. The delayed type hypersensitivity reaction was distinctly suppressed. It also had a suppressive action on serum haemolsin. Only the high dose could decrease serum lipid deroxides and NO contents,and increase superoxide dismutase and glutathione peroxidase levels. CONCLUSION : Tongbizhitong Capsule has suppressive effect on immune function.

关 键 词：通痹止痛胶囊 T淋巴细胞亚群 自由基 免疫抑制 

分 类 号：R285.5[医药卫生—中药学]