肛肠消炎胶囊主要药效学研究  

Study on pharmacodynamics of Gangchangxiaoyan Capsules

作　　者：蒋平[1] 王文清[1] 王晨[1] 林芳[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,湖北武汉430030

出　　处：《中成药》2004年第3期224-226,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :考察肛肠消炎胶囊 (虎杖、没药、乳香、山慈菇、重楼等 )抗菌、抗炎、止痛、活血化瘀的作用。方法 :观察肛肠胶囊对小鼠腹腔注射致病菌并观察其体内抗菌活性 ;以二甲苯致小鼠耳廓水肿和棉球致大鼠肉芽肿法 ,观察其抗炎作用 ;以醋酸致小鼠扭体法 ,观察其止痛作用 ;注射新鲜羊水致家兔微循环障碍造成家兔急性血瘀法 ,观察活血化瘀作用。结果 :实验证明肛肠消炎胶囊对小鼠感染金葡球菌和肠球菌有保护作用 (P <0 .0 0 5 ) ;对醋酸致小鼠扭体反应有明显的抑制作用 (P <0 .0 5或P <0 .0 1) ;能明显降低家兔急性血瘀模型的全血高、低切粘度 (P <0 .0 5或P <0 .0 1)。结论 :肛肠消炎胶囊的药效作用与功能、主治一致。AIM: To probe into the pharmacodynamics of Gangchangxiaoyan Capsules (Rhizoma polygoni Cuspidati,Myrrha,olibanum,Bulbus Iphigeniae Rhizoma paridis,etc) concening antibiotics,antiinflammination,analgesia,promoting blood circulation and eliminating blood stasis. METHODS : Bacterial infection,auricle swollen,granulation swollen,writhing,microcirculation dysfunction caused by amniotic fluid were performed. RESULTS : Gangchangxiaoyan Capsules have remarkable effects on mice bacterial infection(P<0.005),auricle swollen and granulation swollen( P <0.05 or P <0.01);can reduce the writhing response of mice( P <0.05 or P <0.01) and the rabbit's blood viscosity( P <0.05 or P <0.01). CONCLUSION : Gangchangxiaoyan Capules have pharmacological effects in accordance with clinical effects.

关 键 词：肛肠消炎胶囊 抗菌 抗炎 止痛 活血化瘀 小鼠 大鼠 家兔 

分 类 号：R285.6[医药卫生—中药学]