白桦酸及其衍生物的研究进展  

Recent Advances of Betulinic Acid and Its Derivatives

作　　者：李丹[1] 周金培[1] 吴晓明[1] 

机构地区：[1]中国药科大学药学院,江苏南京210009

出　　处：《药学进展》2004年第3期120-125,共6页Progress in Pharmaceutical Sciences

基　　金：200 4年教育部科学技术研究项目 (10 4 2 2 4 )

摘　　要：对白桦酸衍生物的构效关系及其中的YK FH312、RPR10 36 11和IC95 6 4等的作用机制及活性进行述评。天然产物白桦酸是有抗HIV和抗肿瘤活性 ,且具有新型结构和新型作用机制的化合物 ,其天然来源广泛 ,半合成方法成熟 ,是寻找抗HIV和抗肿瘤药物的优秀的先导物。通过对白桦酸的结构修饰 ,大量白桦酸衍生物已被合成。Betulinic acid, a natural product, is an anti-HIV and antitumor agent with novel structure and new mechanism of action. Not only it is found abundantly in the nature, but also its semi-synthesis approach has been successful. Betulinic acid is a perfect lead-compound. A lot of betulinic acid derivatives have been synthesized. The structure-activity relationships of Betulimic acid, The mechanisms and the effects of YK-FH312, RPR103611 and IC9564 derivated from Betulinic acid were reviewed in the paper.

关 键 词：白桦酸 衍生物 研究进展 抗肿瘤药物 作用机制 获得性免疫缺陷综合征 

分 类 号：R931[医药卫生—生药学]