高效液相色谱法测定盐酸噻氯匹定片的含量  

Quantitative Determination of Ticlopidine Hydrochloride Tablets by HPLC

作　　者：陈民辉[1] 贾立革[2] 

机构地区：[1]江苏省药品检验所,南京210008 [2]北京军医学院,北京100071

出　　处：《药学进展》2004年第3期129-131,共3页Progress in Pharmaceutical Sciences

摘　　要：目的 :建立盐酸噻氯匹定片的HPLC含量测定方法。方法 :盐酸噻氯匹定片的HPLC含量测定色谱条件 :ODS柱 ,流动相 :0 1%三乙胺溶液 (磷酸调节pH值为 2 5 ) 甲醇 (6 0∶4 0 ) ,检测波长 :2 33nm ,流速 :1 0ml min。结果 :盐酸噻氯匹定片HPLC含量测定方法的线性范围为 10ng～ 10 μg ,定量限为 10ng,日内RSD为 0 38% ,日间RSD为 0 33%。结论 :本方法简便 ,准确可靠 ,耐用性好。Objective:A HPLC method for quantitative determination of Ticlopidine hydrochloride tablets has been developed. Methods:The HPLC method for detemination of Ticlopidine hydrochloride tablets:ODS column,mobile phase was 0.1% triethylamine(adjusted to pH 2.5 with 85% phosphoric acid)-methanol(60∶40), detector wavelength was 233 nm,flow rate was 1 ml·min -1。Results:The linear range is 10 ng～10 μg,quantitation limit is 10 ng and RSD within day is 0.38% and RSD between days is 0.33%. Conclusion:Those methods are simple and reliable.

关 键 词：高效液相色谱法 盐酸噻氯匹定片 含量测定 色谱条件 

分 类 号：R927.2[医药卫生—药学]