一氧化氮、一氧化碳与血红素的配位化学及其生理作用  

Coordination Chemistry of Heme with Nitric Oxide,Carbon Monoxide and Their Physiological Functions

作　　者：赵慧卿[1] 汪显阳[1] 

机构地区：[1]安徽医科大学化学教研室合肥,230032

出　　处：《化学教育》2004年第3期4-6,共3页Chinese Journal of Chemical Education

基　　金：安徽省高等学校优秀青年教师资助计划项目

摘　　要：NO和CO是新近发现的具有重要生理作用的生物活性小分子 ,其特定的生理效应主要是通过与生物体内血红素蛋白的配位作用产生的。本文比较了NO、CO、O2 与高铁血红素、亚铁血红素的配位化学性质 ,以及它们与亚铁血红素配位所产生的反位效应 。Recently, nitric oxide and carbon monoxide were found to play important roles in many physiological processes. The interaction of NO and CO with the hemoglobin is thought to be the key factor for the unique bio-functions of these small molecules. In this paper, the coordination chemistry of heme and hematosin with NO, CO, O 2 as well as the coordination-induced trans-effect of heme are reviewed. The correlation of physiological functions and the coordination chemistry properties are also introduced.

关 键 词：一氧化氮 一氧化碳 氧气 血红素 配位化学性质 生理作用 高铁血红素 亚铁血红素 相关性 可溶性鸟苷酸环化酶 

分 类 号：R33[医药卫生—人体生理学]