53例甘露醇诱发渗透性肾病的诊治  

Diagnosis and treatment of 53 patients with mannitol-induced osmotic nephrosis

作　　者：杨立明[1] 吕萍[1] 王利然[2] 王启鹏[1] 郭宏艳[1] 杨艳萍[1] 

机构地区：[1]吉林大学第一医院,吉林长春130021 [2]中国人民解放军装甲兵技术学院门诊部,吉林长春130117

出　　处：《药物不良反应杂志》2004年第1期11-14,共4页Adverse Drug Reactions Journal

摘　　要：目的:研究透析、药物等综合治疗甘露醇诱发渗透性肾病的效果。方法:采用血管穿刺或动静脉外瘘进行个体化血液透析/腹膜透析,与药物治疗等综合疗法,对53例(25岁～81岁)甘露醇诱发渗透性肾病患者的治疗效果进行观察及总结。结果:经透析、药物治疗后48名患者病情明显好转,症状逐渐消失,尿量增多、恢复正常,血肌酐(Scr)和尿素氮(BUN)分别由最高1934.8μmol·L-1和49mmol·L-1降至正常。结论:及时恰当透析、药物等综合治疗甘露醇诱发渗透性肾病,能取得满意的疗效。Objective: To investigate the effects of both dialysis and drug treatme nt on mannitol-induced osmotic nephrosis. Method: 53 cases aged 25-81 with manni tol-induced osmotic nephrosis were treated with a combination therapy of drugs and individualized hemodialysis/ peritoneal dialysis. Results: After treatment , much improvement occured in 48 cases, that is, gradual disappearance of sympto ms, normalized urinary output, serum creatinine and blood urea nitrogen decreas ed from 1934.8ìmol/L and 49 mmol/L to normal level respectively. Conclusion: P roper dialysis and drugs therapy could produce a satisfactory effect on mannitol-induced osmotic nephrosis.

关 键 词：甘露醇 渗透性肾病 诊断 治疗 临床资料 急性肾衰竭 ARF ON 

分 类 号：R595.3[医药卫生—内科学]