流行性出血热灭活疫苗加强免疫效果观察  

Observation on Effect of Secondary Immune with Inactivated EHF Vaccine

作　　者：朱智勇[1] 唐汉英[1] 李岩金[1] 翁景清[1] 陆群英[1] 李敏红[1] 俞永新[2] 刘文雪[2] 曾蓉芳[3] 舒浩麒 

机构地区：[1]浙江省卫生防疫站,杭州310009 [2]中国药品生物制品检定所,北京100050 [3]上海生物制品研究所,上海200052

出　　处：《中国病毒学》1992年第4期404-407,共4页Virologica Sinica

摘　　要：流行性出血热(EHF)灭活疫苗对初免一年或一年半后的25名志愿者加强免疫1针,未发现局部和全身副反应,可使初免后中和抗体阴性者或初免后阳性转阴者,中和抗体全部阳转,且中和抗体几何平均滴度与初免相比有成倍的增长。表明此疫苗的初免是有效的,即使初免后未检出中和抗体,但对EHF病毒抗原仍具有强烈的回亿反应,因而EHF灭活疫苗加强免疫是十分必要的。No side effects were found locally and generally in 25 volunteers when the s(?)cordary immunization(one injecton) with inactivated EHF vaccine was done at a year or a year and half after primary immunization, The EHF virus antibodies were detected by PRNT in these volunteers who were negative of neutralization antibody at primary immunization or turned negative from positive, The neutralization antibody GMT (geometial meantitre)after secondary immunization is twice as high as that of primary immunization, The above results showed the primary immunization of inactivatated EHFis effective, AIthough the neutralization antibody had not turn positive after primary immunization, the volunteers possess strong anamnestic reaction to EHF antigen,Therefore the secondary immunization is necessary,

关 键 词：流行性出血热 灭活疫苗 免疫效果 

分 类 号：R392－33[医药卫生—免疫学]