聚α-氰基丙烯酸丁酯载药纳米微粒的研究进展  

The advance in research on drug-loaded nanoparticle of polybutylcyanoacrylate

作　　者：戴蔚荃[1] 周长江[1] 崔黎丽[1] 任宏斌[1] 赵卫权[1] 

机构地区：[1]第二军医大学药学院无机化学教研室,上海200433

出　　处：《药学服务与研究》2004年第1期33-35,共3页Pharmaceutical Care and Research

摘　　要：目的:对作为药物载体的聚α-氰基丙烯酸丁酯的研究进展进行综述,就其制备工艺、体外释药和体内分布、毒理学和稳定性等作一介绍。方法:查阅聚α-氰基丙烯酸丁酯作为载药毫微粒的国内外文献。结果:聚α-氰基丙烯酸丁酯作为药物载体具有生物利用度高、释药速率可控、靶向性,能够改变药物体内分布等优点。结论:聚α-氰基丙烯酸丁酯作为药物载体具有广阔的应用前景。Objective: To review the research of polybutylcyanoacrylate(PBCA) as drug-loaded carrier in recent years, and to introduce the preparation methods, drug releasion in vitro, dispersion in vivo, toxicity and stability of polybutylcyanoacrylate nanoparticle (PBCA-NP). Methods: The related literature at home and abroad was consulted. Results: PBCA as drug-loaded carrier had advantages of high degree of biological utilization, controllable drug release rate, targeting and changing drug distribution in vivo. Conclusion: PBCA as drug-loaded carrier has broad application prospects in the future.

关 键 词：聚α-氰基丙烯酸丁酯 纳米微粒 药物载体 制备工艺 生物利用度 释药速率 

分 类 号：R944.9[医药卫生—药剂学]