用单克隆抗体研究鸡新城疫病毒抗原变异与流行病学的相关性  

Relativity Between Antigenic Variation and Epidemiologic Characters of Newcastle Disease Virus Strains Detected.by Monoclonal Antibodies

作　　者：周维松[1] 刘秀梵[1] 

机构地区：[1]江苏农学院牧医系

出　　处：《中国病毒学》1992年第4期449-455,共7页Virologica Sinica

基　　金：国家"七五"重点攻关项目

摘　　要：用19株抗鸡新城疫病毒(NDV)单克隆抗体(简称单抗)测定与14个NDV国际参考株和16个NDV国内分离株的反应性,将毒株分为a～h 8个群。该组单抗能较精细地测出流行病学上不同的毒株间的抗原变异,毒株分群显示了抗原变异与流行病学特征的相关性。Nineteen monoelonal antibodies (McAb) specific for Newcastle Disease Virus (NDV)was produced and used for the reactivity detection to 14 international reference NDV strains and 16 domestic NDV isolates by indirect immunofluorescent assay (IIF) . According to the results, the 30 NDV strains was divided into 8 groups from a to h. The antigenic variation of the strains which are different in epidemiology could be estimated by IIP test using the 19 MeAbs. It was showed tl, at there is relativity between antigenic variation and epidemiologic characters of NDV strains by the grouping of the 30 NDV strains In addition, antigenic different virions were found to exist in Lasota strain.

关 键 词：鸡新城疫病毒 单克隆抗体 抗原变异 

分 类 号：S852.65[农业科学—基础兽医学]