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作 者:喻方迩 董文度[1] 周又夫 刘官成[1] 汤志诚 丁勇[1] 周其锦 余有训 张秀蓉 王亮
机构地区:[1]海军医学专科学校
出 处:《中国病理生理杂志》1992年第1期80-85,共6页Chinese Journal of Pathophysiology
摘 要:本实验用健康成年绵羊16只,向气管内注入海水(6ml/kg)造成溺水模型。于溺水后10分钟,使用高频通气治疗。对照组不使用高频通气治疗。分别于溺水前及溺水后5、15、30、40、70、130min采取股动脉血测定指标:1.血清过氧化脂质(LPO),两组中均于溺水后短时间降低,后又迅速上升达溺水前10倍以上。2.TXB_2、6-keto-PGF_(1α)在两组中均增加。3.pH在对照组中明显降低,(7.133~7.219)。4.PaO_2在对照组中降低较为显著。5.PaCO_2在溺水后5、15min时轻度上升。6.血中K^+、Na^+、Cl^-两组中轻度升高,但高频通气组于溺水后60min即恢复正常。7.两组肺超微结构变化基本相似。作者认为高频通气治疗海水溺水虽有一定效果,但不满意。尚需采用其它新的治疗手段提高救治率。A standardized near-drowning procedure was carried out on 16 adult normal sheep. Six milliliter sea water/kg body wt were introduced into the trachea by a tube. Ten minutes after near-drowning, eleven sheep were treated with HFV(HFVgroup), and the other 5 without HFV(NHFV group). Before near-drowning and at 5,15,30,40, 70,and 130 minutes afterward the measurement were made and it was found that: 1. Serum lipoperoxide(LPO) decreased for a short time, and then increased ten folds in both groups. 2. TXB_2 and 6-keto-PGF_(1α) increased in both groups. 3. pH decreased in NHFV groups(7.133—7.219). 4. PaO_2 decreased much mose in NHFV group. 5.PaCO_2 increased slightly at 5, 15 minutes after near-drowning; 6.K^+, Na^+, CI-increased slightly in both groups, and then returned to normal at 70 minutes after near-drowning. In HFV group; the changs of pulmonary ultrastructure after near-drowning were similar in both groups. The authors concluded that HFV showed some effects but is not satisfactory. We must find other treating methods to improve survival rate.
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