中枢儿茶酚胺与血管紧张素在一肾Grollman高血压中的作用  

Investigation on the role of central catecholamine and angiotensin Ⅱ in one-kidney Grollman hypertension in rats

作　　者：杨焜[1] 王青[1] 沈晓云 卢刚[1] 

机构地区：[1]同济医科大学生理教研室高血压实验室

出　　处：《中国病理生理杂志》1992年第2期192-194,共3页Chinese Journal of Pathophysiology

基　　金：国家科委资助

摘　　要：在一肾Grollman高血压大鼠研究了中枢儿茶酚胺(CA)与血管紧张素Ⅱ(AⅡ)于高血压的后期(维持期)听起的作用。结果发现在高血压维持期大鼠脑(延脑、下丘脑)内去甲肾上腺素(NE)、肾上腺素(E)及AⅡ含量显著高于同龄对照组。经高血压大鼠侧脑室分别注射6-OHDA与Captopril,血压均显著下降,脑内NE、E及AⅡ含量亦均显著减少。此外,发现此高血压大鼠的动脉压力反射敏感性显著降低,侧脑室注射Captopril后又明显回升。The role of central catecholamine (CA) and angiotensin Ⅱ (AⅡ) in one-kidney Grollman hypertensive rats was investigated. Arterial blood pressure was measured by indirect tail-plethysmography, and the contents of norepinephrine(NE), epinephrine(E) and AⅡ in hypothalamus and medulla oblongata were determined by means of fluorimetry and immunoradioassay respectively. The results showed that during the maintenance period of one-kidney Grollman hypertension the brain contents of NE E and AⅡ were significantly higher than that of the age-matched sham-wrapped rats. Separate intracerebroventricular injections of 6-OHDA and captopril not only induced significant decline of arterial blood pressure but also induced reduction of NE, E and AⅡ in the brain areas. Besides, the arterial baroreflex sensitivity in one-kidney Grollman hypertensive rats was markedly decreased. It suggests that the increase of NE, E and AⅡ and the decrease of the arterial baroreflex sensitivity may play an important role in one-kidney Geallmon hyportension.

关 键 词：高血压 儿茶酚胺类 血管紧张素 

分 类 号：R544.1[医药卫生—心血管疾病]