实验性重症减压病时血小板组织超微结构的变化  

Ultrastructural changes in platelets with experimental severe decompression sickness

作　　者：辛佩珠[1] 魏元良[1] 王风瑞 项光强[1] 李政年[1] 韦毅[1] 

机构地区：[1]海军医学研究所

出　　处：《中国病理生理杂志》1992年第3期285-288,共4页Chinese Journal of Pathophysiology

摘　　要：本文研究了动物(家兔、山羊、大鼠)实验性重症减压病时血液、血管壁及心、肺、肝、肾等组织的形态学超微结构的变化特点。用SEM及TEM观察了在0.6MPa和1.0MPa压力下形成的重症减压病的超微结构变化。结果表明,血小板、红细胞变形、血管内皮细胞间隙增宽、气-血界面形成、血管内血栓形成、细胞内线粒体肿胀、RER扩张和膜脱粒。血小板数下降,聚集功能增加,1/2最大聚集率增加。提示血小板的变化在减压病的发生、发展中起一定重要作用。The present study describes systematically the ultrastructural changes of blood and some organs of rabbits, goats and rats with severe decompression sickness. In our experiment, the animals were exposed to pressure of 0.6 MPa and 1.0 MPa for 60 minutes respectively, to induce severe decompression sickness. The results are as follows: 1. Abnormality of platelets. The granules of platelets decreased and the platelet pseudopods were formed with adhesion and aggregation of platelets. 2. Deformation of erythrocytes. Triangle-like or shell-like cells, dacryocytes, twisted cells, and Ⅰ—Ⅲ type echinocytes were found. 3. Changes of endotheliocytes of the vascular wall became flattened. The space between these cells significantly widened (up to 4-18μm), and blood cells could be found to have wedged into it. 4. Formation of air-blood surface by the intravascular blood. 5. Alteration of organelies. There occured the expansion of rough endoplasmic reticulum, the degranulation and rupture of membranes, as well as the swelling and dissolution of mitochondria.

关 键 词：减压病 超微结构 血小板 

分 类 号：R845.21[医药卫生—航空、航天与航海医学]