实验性哮喘时下呼吸道和血液中CGRP含量的变化  

Alteration of calcitonin gene related peptide in the respiratory tract and circulating blood of the experimental asthma

作　　者：方秀斌[1] 于频[1] 王铁民[1] 

机构地区：[1]中国医科大学脑研究所

出　　处：《中国病理生理杂志》1992年第4期406-408,共3页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金

摘　　要：应用放射免疫分析方法,测定了16只哮喘豚鼠下呼吸道各部组织和循环血液中降钙素基因相关肽(CGRP)的水平。与健康对照组(气管52.6±20.3,支气管58.3±16.1,左肺上叶65.2±14.6 pg/g,血液130.6±32.3 pg/ml(?)±SD)相比,哮喘豚鼠下呼吸道和血液中CGRP的水平(气管68.8±15.5,支气管77.6±20.5,左肺上叶83.3±18.7ps/g湿重P<0.05;血液193.6±26.5 Pg/ml(?)±sD P<0.001)显著升高。这些结果提示,CGRP可能参与哮喘发作的病理生理过程,是其发作的因素之一。The level of calcitonin gene related peptide (CGRP) in the lower respiratory tract and circulating blood of 16 experimental asthmatic guinea pigs has been measured using radioimmunoassay. The level of CGRP in the lower respiratory tract and blood of the asthmatic guinea pigs was increased significantly (trachea 68.8±15.5, bronchus 77.6±20.5, upper lobe of left lung 83.3±18.7 Pg/g, P<0.05 wet tissue; blood 193.6±26.5 pg/ml P<0.001 (?)±SD) in comparison with the normal controls (trachea 52.6± 20.3, bronchus 58.3±16.1, upper lobe of left lung 65.2±.14.6 Pg/g wet tissue; blood 130.6±32.3 pg/ml). These data suggest that CGRP may play an important role in the pathogenesis of asthma.

关 键 词：哮喘 呼吸系统 降钙素基因 相关肽 

分 类 号：R562.250.2[医药卫生—呼吸系统]