吸烟对多形核白细胞的丙二醛含量及超氧化物歧化酶活性的影响  

Effects of cigarette smoking on oxidative metabolism of human polymorphonuclear leukocyte, and the activity of serum superoxide dismutase

作　　者：徐军[1] 侯恕[1] 

机构地区：[1]广州呼吸病研究所

出　　处：《中国病理生理杂志》1992年第6期637-640,共4页Chinese Journal of Pathophysiology

摘　　要：比较了非吸烟,吸烟,吸烟并慢阻肺者动脉血多形核白细胞的脂质过氧化产物—丙二醛(MDA)含量以及细胞和血清的抗氧化酶—超氧化物歧化酶(SOD)的活性。结果表明:吸烟和吸烟并慢阻肺者多形核白细胞的MDA以及SOD活性高于非吸烟者(P<0.01,P<0.05)。血清SOD则吸烟者低于不吸烟者(P<0.01)。MDA含量与SOD活性间的相关分析提示:吸烟者多形核白细胞的SOD处于相对不足,血清SOD绝对不足,练上所述:长期吸烟可使血中氧化和抗氧化失去平衡。To investigate the possible role of oxygen free radical in the development of COPD related to cigarette smoking, we studied polymorphonuclcar leukocyte (PMN) oxidative metablism in asymptomatic smokers, smokers with COPD and the control. It was found that the content of PMN-MDA(PMN-malondialdehyde) and the activiy of SOD(superoxide dismutase) of asymptomatic smokers and smokers with COPD significant higher than that of the control. (P<O.01, P<0.05 respectively). Serum SOD of smokersand smokers with COPD was lower than that of the control (P<0.01). The stepwise regression analysis between PMN-MDA and PMN-SOD indicated that the elevation of PMNSOD was relatively insufficient presented in smokers and smokers with COPD, although their PMN-SOD level became higher as the PMN-MDA increased. These results suggest that cigarette smoking might cause an imbalance between oxidative and antioxidative metabolism in blood, which may contribute to lung injury.

关 键 词：白细胞 肺疾病 吸烟 超氧物歧化酶 

分 类 号：R563.02[医药卫生—呼吸系统]