环丙沙星对多索茶碱药物动力学的影响  

Effects of Ciprofloxacin on pharmacokinetics of Doxofylline in healthy rabbits

作　　者：孙西征[1] 姜云平[2] 卢熙[3] 张丽娜[2] 申恒税[4] 

机构地区：[1]第三军医大学成都军医学院药学教研室,四川成都610083 [2]成都军区总医院药学部,四川成都610083 [3]成都军区防疫大队,四川成都610021 [4]四川大学华西药学院

出　　处：《华西药学杂志》2004年第2期107-109,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的 研究环丙沙星对多索茶碱在家兔体内的药物动力学的影响。方法 采用RP-HPLC法,测定10只家兔多剂量服用盐酸环丙沙星片前、后,口服多索茶碱的血药浓度,以3p87药动学软件按二室模型对数据进行处理并进行统计分析。结果 单用和合用环丙沙星后多索茶碱的Tmax分别为0.44±0,26 h、0.50±0.28 h,Cmax分别为4.93±2.75、5.72±3.04 μg·ml-1,T1/2β分别为7.36±2.96 h、9.35±3.38 h,AUC0→t分别为12.86±7.88、17.40±7.64μg·h·ml-1。 结论 两药联用时,环丙沙星对多索茶碱的Tmax和Cmax没有影响,对T1/2β和AUC0→t有影响,抑制了多索茶碱的代谢排泄。OBJECTIVE To study the effect of Ciprofloxacin on pharmacokinetics of Doxofvlline in healthy rabbitts, METHODS The plasma concentrations of Doxofvlline were determined by HPLC and analyzed by 3p87 pharmacokinetic program. RESULTS The main pharmacokinet-ic parameters of Doxoiylline and that with concomitant Ciprofloxacin were as follows: Tmax were 0.44±0,26 h and 0.50±0.28 h; Cmax were 4.93±2.75 μg·ml-1 and 5.7β3.04 μg·ml-1; T1/β± were 7. 36±2.96 h and 9. 35±3. 38 h;AUC0→1, were 12.86±7. 88 μg·ml-1 and 17.40±7.64 μg·ml-1,. respectively. CONCLUSION The AUC and T1/β± of Doxofvlline with concomitant Ciprofloxacin were increased (P < 0.05) .There was no effect of Ciprofloxacin on Tmax, Cmax of Doxoiylline.

关 键 词：环丙沙星 多索茶碱 药物动力学 高效液相色谱仪 血药浓度 

分 类 号：R969.1[医药卫生—药理学] R974[医药卫生—药学]