电针内关穴对内毒素休克肾组织诱导型NO合酶表达的影响  

Influence of Electroacupuncture of Point Neiguan (PC6) on iNOS Expression in Kidney of Endotoxin Shock Rats

作　　者：邓汝东[1] 李伊为[1] 陈东风[1] 杜少辉[2] 黎辉[1] 

机构地区：[1]广州中医药大学解剖教研室,广州510405 [2]广东省深圳市中医院内科,深圳518033

出　　处：《广州中医药大学学报》2004年第1期31-33,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金(编号:39970914);广东省中医药管理局项目(编号:98447);深圳市科技局项目(编号:200004087)

摘　　要：【目的】探讨电针内关穴对内毒素休克肾组织诱导型一氧化氮合酶(iNOS)表达的作用。[方法]采用脂多糖(LPS)和D氨基半乳糖(D-GalN)致敏的内毒素休克模型,应用免疫组织化学技术检测肾组织iNOS的表达,观察电针内关穴对内毒素休克肾组织iNOS表达的影响。[结果]电针内关穴组的肾组织iNOS的表达低于内毒素模型对照组(P<0.01)。[结论]电针内关穴能部分下调内毒素休克所致肾iNOS的过度表达,这可能是其治疗内毒素休克的机理之一。[Objective] To observe the effect of electro-acupuncture (EA) on point Neiguan (PC6) on inducible nitric oxide synthase (iNOS) expression in kidney df endotoxin shock rats. [Methods] The model of endotoxin shock was induced by lipopolysaccharide (LPS) and D-galactosamine. The expression of iNOS in kidney was measured by immunohistochemistry method. [Results] The expression of iNOS was weaker in EA group than that in model group (P <0.01). [Conclusion] EA on point Neiguan can partially regulate the over-expression of iNOS in kidney with endotoxin shock and this may be one of its therapeutic mechanism.

关 键 词：内毒素休克 肾 一氧化氮合酶 内关穴 电针 免疫组织化学 

分 类 号：R269.314[医药卫生—中西医结合] R245.97[医药卫生—中医外科学]