仙灵骨葆对PMO骨密度及IL-6、TNF-α、IGF-I的影响  

Effects of Xianling Gubao capsule on bone mineral density and cytokines in postmenopausal osteaporlofic Patients.

作　　者：张秀珍[1] 韩峻峰[1] 钱国峰[1] 贺铭[1] 李颖[1] 谷磊[1] 

机构地区：[1]同济大学附属同济医院内分泌科,上海200065

出　　处：《中国骨质疏松杂志》2004年第1期90-93,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金资助项目(30070357)

摘　　要：目的 观察仙灵骨葆(XLGB)治疗绝经后骨质疏松症(Postmenopausal Oeteoporosis,PMO)骨密度(BMD)及白介素6(IL-6)、肿瘤坏死因子(TNF-α)、胰岛素样生长因子(IGF-I)及骨代谢指标的变化。方法 选择年龄55-60岁的PMO共178例,随机分为:XLGB组62例,利维爱(Livial)组66例,钙剂组50例和年龄相匹配的正常妇女20例作对照组。各组均于用药前、后24、28周采用DEXA骨密度仪测定BMD;放免法测定E2、碱性磷酸酶(ALP)水平;定量夹心酶联免疫法(ELISA)测定骨钙素(BGP)、Ⅰ型胶原N末端肽(NTx)、IL-6、TNF-α、IGF-I水平。结果 XLGB组和Livial组BMD较治疗前均有不同程度的提高,以Total为显著(增幅分别为2.95％,4.40％,P<0.001)。Lival组E2水平明显上升(P<0.01),IL-6、TNF-α、NTX下降(P<0.01);xLGB组E2水平无变化(P>0.05),但IGF-I明显升高(P<0.01),余变化同前;钙剂组和对照组各部位BMD、E、IGF-I、ALP、BGP继续下降(P<0.05),而IL-6、TNF-α、NTX升高(P<0.05)。结论 XLGB治疗PMO疗效显著,与Livial相仿。单纯服用钙剂不能治疗PMO,且继续骨量丢失。Objective To study the effects of Xianling Gubao XLGB capsule on bone mineral density and cytokines in patients with postmenopausal osteopossis(PMO). Methods 178 PMO patients aged from 55 to 60 years were randomized in to three groups. All of them received Leli capsules (calcium preparation) 1.0g/day. Group A, 62 patients, received XLGB capsules 1.0g, bid; group B, 66 patients, received livial 1.25 mg/day, group 50 patients received Lele capsules only. 20 women, 55-60(57.4 ± 3.54) years old, were recruited as normal controls. Dual-energy X-ray absorptiometry and measurements of a series of biochemical indices were performed before and after medication at 24 and 48 weeks. Results After medication, BMD increased in XLGB and Livial groups, especially in femur (Total). In Livial group, the levels of E2 increased rapidly (P < 0.01),while levels of IL-6, TNF-a and NTX decreased ( P < 0.01). In XLGB group, no changes in levels of E2 occurred , while levels of IGF-I increased ( P < 0.01) ;the other indices were the same as in Livial group. In Leli group and control group, BMD E2 , ALP, BGP and IGF-I decreased ( P < 0.05), while levels of IL-6,TNF-α and NTX increased (P<0.05). Conclusion XLGB significantly improves BMD as Livial does. Thus it plays an important role in the treatment of osteoporosis. But calcium tablet can not prevent the loss of bone.

关 键 词：仙灵骨葆 PMO 骨密度 IL-6 TNF-α IGF-I 绝经后 骨质疏松症 白介素6 肿瘤坏死因子-α 胰岛素样生长因子-I 

分 类 号：R274.91[医药卫生—中西医结合]