碘氟在实验性甲状腺肿和氟中毒发病中的联合作用  

THE STUDY OF IODINE AND FLUORINE COMBINE ACTION ON EXPERIMENTAL GOITER AND FLUROSIS

作　　者：赵文元[1] 朱惠民[1] 高优真[1] 姚玉霞 秦立[1] 陈崇义[1] 于志恒[1] 

机构地区：[1]河北医学院环境卫生学教研室

出　　处：《中国地方病防治》1992年第1期16-18,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：按3×3析因试验的方法将13～15g雄性昆明种小鼠分为9组,经饮水施加实验处理。碘(I)、氟(F)各选缺乏(D),适量(M)和过量(E)三个剂量,水碘浓度分别是0.0、20.0和2500.0μg/L,水氟浓度为0.0、0.6和30.0mg/L。实验发现①在100天氟可加强碘缺乏、抑制碘过量的致甲状腺肿能力,而150天氟加强过量碘、抑制碘缺乏的致甲胂作用;②在实验第30、60、90和150天,碘缺乏情况下氟对骨和牙的毒作用最强。Male Kunming strain mice weighted 13-15g were divided into nine groups according to the 3X3 factorial experimental method.We added iodate(I) and fluoride (F) into the mice drinking water with varying doses as simplified D. M. and E.as deficiency, medium and excess respectively.Iodine contents in the water were 0.0, 20.0 and 2500.0ug/L for I.D.,I.M.,I.E. groups, and the fluorine concentrations were 0.0,0.6,30.0mg/L for F.D.,F.M. and F.E.groups respectively. On 100th and 150th day after this experiment started, we observed that there were some combine actions with iodine and fluorine:①fluorine was able to influence the goitrogenicity in both I.D. and I.E. groups, and the influences of two groups varied on 100th and 150th day;② on 30th, 60th,90th and 150th day,fluorine had a maximum toxic effect on bone and teeth under the condition of iodine deficiency.

关 键 词：碘 氟 甲状腺肿 氟中毒 

分 类 号：R599.02[医药卫生—内科学]