垂体—甲状腺系统在慢性布病发病中的作用  

THE FUNCTION OF PATHOGENESIS OF HYPOPHYSIS THYROID GLAND SYSTEM IN CHRONIC BRUCELLOSIS

作　　者：张士义[1] 王大力[1] 杨跃清[1] 李安娜[1] 刘凤歧[1] 丛显斌[1] 张桂珍[1] 何玉萍[1] 王季秋[1] 刘春光[1] 张新飞[1] 

机构地区：[1]吉林省地方病第一防治研究所

出　　处：《中国地方病防治》1992年第4期206-208,226,共4页Chinese Journal of Control of Endemic Diseases

摘　　要：通过对67例慢性布氏菌病(下称布病)患者和30例健康人血清中的T_3、T_4及TSH含量测定,结果表明部分慢性布病患者存在着一定程度垂体—甲状腺系统的功能紊乱,表现潜隐或轻度甲状腺机能减退,而垂体TSH分泌功能代偿性增强。并与实验性慢性布病豚鼠血清中T_3、T_4及TSH含量测定结果基本一致。同时通过实验性布病豚鼠甲状腺组织病理形态学观察,证实了慢性布病机体表现该系统功能紊乱是有其病理形态学基础的。本研究对象深刻认识慢性布病发病机理具有一定的理论意义和实用价值。The result with T_3, T_4 and TSH measurement from 67 patients of chronic brucellosis and healthy persons showed that the function disordered of hypophysis-thyroid gland system in a certain degree in some chronic brucellosis patients,and showed latent or the function of thyroid gland come down hightly. However,secrete function of hypophysis TSH was compensable enhancement.This result was same as in the main that of guinea-pigs with experimental chronic brucellosis. Besides, pathomorphology which thyroid gland tissue of guinea pigs in experimental brucellosis was observed. It has been confirmed that the Junction of the system disorder was on the basis of pathomorphology of chronic brucellosis organism. This observation results showed that there are certain significance of theory and practicalnees value for make penetrating analysis pathogenic mechanism of chronic brucellosis.

关 键 词：垂体 甲状腺 布鲁氏菌病 

分 类 号：R516.702[医药卫生—内科学]