锌硒对大鼠谷胱甘肽过氧化物酶和超氧化物歧化酶影响  

Effect of Selenium and Zinc on the actvities of GSH-px and CuZn-SOD

作　　者：刘金林 苏引[2] 吴振荣[2] 路雪松[2] 许永丽[2] 

机构地区：[1]青岛卫生防疫站 [2]中国地方病防治研究中心克山病研究所

出　　处：《中国地方病学杂志》1992年第4期196-198,共3页Chinese Jouranl of Endemiology

摘　　要：通过在大鼠饲料中添加不同量的锌硒实验表明,补硒可提高大鼠全血和肝脏谷胱甘肽过氧化物酶(GSH-px)活性,而补锌未呈现对全血和肝脏 GSH-px 活性影响;补锌或补硒对大鼠红细胞铜锌超氧化物歧化酶(CuZn-SoD)活性无显著影响,但补锌可提高肝脏 CuZn-SoD活性,硒对肝脏 CuZn-SoD 活性影响不明显;锌和硒对 GSH-px 和 CuZn-SoD 活性的影响无明显交互作用存在。This study was intended to observe the effects of selenium and Zinc onthe activities of GSH-Px and CuZn-SOD in rat blood and liver throughadding the elements at different levels to the diet.the data obtained indicatedthat(1)supplementation of Selenium could enhance the activity of GSH-Pxof blood and liver,while no effect was found with Zinc supplemented;(2)supplementation of neither Selenium nor zinc acted on the activities of thetwo enzymes,but the activity of CuZn-SOD in liver could be elevated withZinc added and (3) there was no interaction found of Selenium and Zinc onactivites of the two enzymes.

关 键 词：锌 硒 谷胱甘肽 过氧化物酶 铜 SOD 克山病 

分 类 号：R542.3[医药卫生—心血管疾病]